Concepedia

Self-immolative Linkers

Self-Immolative Linker is a specialized type of molecular spacer in prodrug design that, upon cleavage of a triggering moiety, undergoes spontaneous intramolecular rearrangement to release the active drug molecule without leaving residual linker fragments attached to the drug.

116

Publications

4.7K

Citations

557

Authors

149

Institutions

Publications per year

2017–2026

64

Variants

Self-immolative Spacers

Parents

Children

Publications

116

Quinone-Methide Species, A Gateway to Functional Molecular Systems: From Self-Immolative Dendrimers to Long-Wavelength Fluorescent Dyes

Samer Gnaim, Doron Shabat · Accounts of Chemical Research · 2014 · 208 citations

, , +15

Detection and Cellular Imaging of Human Cancer Enzyme Using a Turn-On, Wavelength-Shiftable, Self-Immolative Profluorophore

Suraj U. Hettiarachchi, Bijeta Prasai, Robin L. McCarley · Journal of the American Chemical Society · 2014 · 184 citations · Full text

, , +17

Thiol–Chromene “Click” Reaction Triggered Self-Immolative for NIR Visualization of Thiol Flux in Physiology and Pathology of Living Cells and Mice

Yu-Tao Yang, Tingting Zhou, Ming Jin et al. · Journal of the American Chemical Society · 2019 · 179 citations

, , +17

Self-immolative linkers in polymeric delivery systems

Christopher A. Blencowe, Andrew T. Russell, Francesca Greco et al. · Polymer Chemistry · 2010 · 150 citations · Full text

, , +17

The structural basis of autotransporter translocation by TamA

Fabian Gruss, Franziska Zähringer, Roman P. Jakob et al. · Nature Structural & Molecular Biology · 2013 · 136 citations

, , +9

1–5 of 116

Authors

557

  1. DS
    Doron Shabat

    Tel Aviv University, Israel

    7 publications · 458 citations

    7

    h-index

  2. CG
    Cesare Gennari

    University of Milan, Italy

    6 publications · 142 citations

    6

    h-index

  3. AD
    Alberto Dal Corso

    University of Milan, Italy

    5 publications · 127 citations

    5

    h-index

  4. LB
    Laura Belvisi

    University of Milan, Italy

    5 publications · 127 citations

    5

    h-index

  5. LP
    Luca Pignataro

    University of Milan, Italy

    5 publications · 127 citations

    5

    h-index

1–5 of 557

Institutions

149

  1. Centre National de la Recherche Scientifique

    Paris, France

    10 h-index

    46 publications

    1.9K citations

  2. University of Milan

    Milan, Italy

    7 h-index

    37 publications

    807 citations

  3. Tel Aviv University

    Tel Aviv, Israel

    7 h-index

    24 publications

    1.2K citations

  4. Western University

    London, Canada

    4 h-index

    10 publications

    387 citations

  5. Aarhus University

    Aarhus, Denmark

    4 h-index

    15 publications

    576 citations

  6. Université de Rouen Normandie

    Rouen, France

    4 h-index

    22 publications

    1.3K citations

  7. Institut Curie

    Paris, France

    3 h-index

    11 publications

    243 citations

  8. Université de Poitiers

    Poitiers, France

    3 h-index

    8 publications

    335 citations

1–8 of 149

Venues

  1. Bioconjugate Chemistry

    9 publications · 369 citations

    10

    h-index

  2. Chemical Communications

    ChemComm · 9 publications · 330 citations

    10

    h-index

  3. Organic & Biomolecular Chemistry

    8 publications · 321 citations

    8

    h-index

  4. Journal of the American Chemical Society

    JACS · 6 publications · 601 citations

    6

    h-index

  5. Journal of Medicinal Chemistry

    5 publications · 238 citations

    6

    h-index

1–5