Concepedia

Selectivity Filter Energetics

Selectivity Filter Energetics is a theoretical framework in ion channel biophysics that characterizes the free energy landscape governing ion selectivity within the selectivity filter of transmembrane channels by quantifying the energetic contributions of ion coordination, dehydration, and electrostatic interactions specific to the filter's atomic structure.

58

Publications

4.5K

Citations

187

Authors

107

Institutions

Publications per year

2017–2026

10

Parents

Publications

58

Energetic optimization of ion conduction rate by the K+ selectivity filter

João H. Morais‐Cabral, Yufeng Zhou, Roderick MacKinnon · Nature · 2001 · 852 citations

, , +16

The Occupancy of Ions in the K+ Selectivity Filter: Charge Balance and Coupling of Ion Binding to a Protein Conformational Change Underlie High Conduction Rates

Yufeng Zhou, Roderick MacKinnon · Journal of Molecular Biology · 2003 · 425 citations

, , +16

Spatial Localization of the K+ Channel Selectivity Filter by Mutant Cycle–Based Structure Analysis

Rama Ranganathan, John H. Lewis, Roderick MacKinnon · Neuron · 1996 · 292 citations · Full text

, , +15

The mechanism of proton exclusion in aquaporin channels

Boaz Ilan, Emad Tajkhorshid, Klaus Schulten et al. · Proteins Structure Function and Bioinformatics · 2004 · 168 citations

, , +17

Mutational Analysis of the Charge Selectivity Filter of the α7 Nicotinic Acetylcholine Receptor

Pierre‐Jean Corringer, Sonia Bertrand, Jean‐Luc Galzi et al. · Neuron · 1999 · 161 citations

, , +13

1–5 of 58

Authors

187

  1. RM
    Roderick MacKinnon

    Howard Hughes Medical Institute, United States

    3 publications · 1.4K citations

    3

    h-index

  2. MS
    Mark S.P. Sansom

    University of Oxford, United Kingdom

    3 publications · 283 citations

    3

    h-index

  3. DH
    Douglas Henderson

    Brigham Young University, United States

    3 publications · 85 citations

    3

    h-index

  4. TL
    Thomas L. Beck

    University of Cincinnati, United States

    2 publications · 46 citations

    2

    h-index

  5. MB
    Manasi Bhate

    Columbia University, United States

    2 publications · 135 citations

    2

    h-index

1–5 of 187

Institutions

107

  1. University of Oxford

    Oxford, United Kingdom

    5 h-index

    14 publications

    1.2K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    4 h-index

    10 publications

    3K citations

  3. Columbia University

    New York, United States

    3 h-index

    12 publications

    905 citations

  4. Rockefeller University

    New York, United States

    3 h-index

    6 publications

    2.8K citations

  5. Brigham Young University

    Provo, United States

    3 h-index

    8 publications

    204 citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    9 publications

    739 citations

  7. University of Illinois Urbana-Champaign

    Urbana, United States

    3 h-index

    6 publications

    568 citations

  8. University of California, Davis

    Davis, United States

    2 h-index

    4 publications

    408 citations

1–8 of 107

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 9 publications · 723 citations

    9

    h-index

  2. Biophysical Journal

    7 publications · 485 citations

    7

    h-index

  3. The Journal of Chemical Physics

    3 publications · 110 citations

    3

    h-index

  4. Journal of the American Chemical Society

    JACS · 3 publications · 83 citations

    3

    h-index

  5. Journal of Molecular Biology

    JMB · 3 publications · 639 citations

    3

    h-index

1–5