Concepedia

Seeded Protein Aggregation

Seeded Protein Aggregation is a molecular mechanism in prion biology where pre-existing misfolded protein aggregates act as templates to catalyze the conformational conversion and subsequent aggregation of native proteins into ordered, self-propagating amyloid fibrils.

69

Publications

6K

Citations

390

Authors

155

Institutions

Publications per year

2017–2026

37

Parents

Publications

69

Nucleated Conformational Conversion and the Replication of Conformational Information by a Prion Determinant

Tricia R. Serio, Anil G. Cashikar, Anthony S. Kowal et al. · Science · 2000 · 964 citations · Full text

, , +17

Self-Seeded Fibers Formed by Sup35, the Protein Determinant of [PSI+], a Heritable Prion-like Factor of S. cerevisiae

John R. Glover, Anthony S. Kowal, Eric C. Schirmer et al. · Cell · 1997 · 599 citations · Full text

, , +13

Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading

Marija Iljina, Gonzalo Garcia, Mathew H. Horrocks et al. · Proceedings of the National Academy of Sciences · 2016 · 231 citations · Full text

, , +17

Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation

Hilda Mirbaha, Brandon B. Holmes, David W. Sanders et al. · Journal of Biological Chemistry · 2015 · 229 citations · Full text

, , +9

Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration

Xinhe Wang, Katelyn Becker, Nathan Levine et al. · Acta Neuropathologica Communications · 2019 · 215 citations · Full text

, , +17

1–5 of 69

Authors

390

  1. BC
    Byron Caughey

    National Institute of Allergy and Infectious Diseases, United States

    8 publications · 514 citations

    8

    h-index

  2. AG
    Andrew G. Hughson

    National Institute of Allergy and Infectious Diseases, United States

    6 publications · 269 citations

    6

    h-index

  3. AK
    Allison Kraus

    National Institute of Allergy and Infectious Diseases, United States

    4 publications · 325 citations

    4

    h-index

  4. SM
    Shigeo Murayama

    Tokyo Metropolitan Institute of Gerontology, Japan

    4 publications · 435 citations

    4

    h-index

  5. BR
    Brent Race

    National Institute of Allergy and Infectious Diseases, United States

    4 publications · 129 citations

    4

    h-index

1–5 of 390

Institutions

155

  1. University of Cambridge

    Cambridge, United Kingdom

    6 h-index

    37 publications

    3.9K citations

  2. National Institutes of Health

    Bethesda, United States

    5 h-index

    29 publications

    1.4K citations

  3. National Institute of Allergy and Infectious Diseases

    Bethesda, United States

    5 h-index

    38 publications

    1.9K citations

  4. UK Dementia Research Institute

    London, United Kingdom

    4 h-index

    16 publications

    482 citations

  5. University College London

    London, United Kingdom

    4 h-index

    19 publications

    2K citations

  6. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    4 h-index

    13 publications

    2K citations

  7. Howard Hughes Medical Institute

    Chevy Chase, United States

    4 h-index

    19 publications

    10K citations

  8. University of Edinburgh

    Edinburgh, United Kingdom

    3 h-index

    8 publications

    298 citations

1–8 of 155

Venues

  1. Journal of Biological Chemistry

    JBC · 8 publications · 777 citations

    8

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 6 publications · 907 citations

    6

    h-index

  3. Prion

    4 publications · 48 citations

    4

    h-index

  4. PLoS ONE

    4 publications · 137 citations

    4

    h-index

  5. Acta Neuropathologica Communications

    4 publications · 374 citations

    4

    h-index

1–5