Concepedia

Second Messenger Pathways

Second Messenger Pathways is a biochemical signaling mechanism that transduces extracellular hormonal stimuli into intracellular responses through the generation of diffusible signaling molecules, distinguishing it from direct enzyme-linked or nuclear receptor pathways by its reliance on relay molecules such as cAMP, calcium, or inositol trisphosphate to amplify and propagate the signal.

707

Publications

50.9K

Citations

2.7K

Authors

716

Institutions

Publications per year

2017–2026

41

Parents

Publications

707

Inositol trisphosphate, a novel second messenger in cellular signal transduction

Michael J. Berridge, Robin F. Irvine · Nature · 1984 · 6.1K citations

, , +16

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

Andrea Ablasser, Marion Goldeck, Taner Cavlar et al. · Nature · 2013 · 1.6K citations · Full text

, , +12

GGDEF and EAL domains inversely regulate cyclic di‐GMP levels and transition from sessility to motility

Roger Simm, Michael Morr, Abdul Kader et al. · Molecular Microbiology · 2004 · 1K citations · Full text

, , +12

Micro-injection of inositol 1,3,4,5-tetrakisphosphate activates sea urchin eggs by a mechanism dependent on external Ca2+

Robin F. Irvine, R. M. Moor · Biochemical Journal · 1986 · 773 citations · Full text

, , +16

The Action of Oncogenes in the Cytoplasm and Nucleus

Robert A. Weinberg · Science · 1985 · 701 citations

, , +17

1–5 of 707

Authors

2.7K

  1. HB
    Heinz Breer

    University of Hohenheim, Germany

    8 publications · 681 citations

    8

    h-index

  2. PD
    Patrick Doherty

    King's College London, United Kingdom

    8 publications · 603 citations

    8

    h-index

  3. JA
    James A. Nathanson

    Massachusetts General Hospital, United States

    5 publications · 400 citations

    5

    h-index

  4. IB
    Ingrid Boekhoff

    University of Hohenheim, Germany

    5 publications · 589 citations

    5

    h-index

  5. KK
    Kyuya Kogure

    Tohoku University, Japan

    5 publications · 143 citations

    5

    h-index

1–5 of 2.7K

Institutions

716

  1. Harvard University

    Cambridge, United States

    16 h-index

    46 publications

    3.2K citations

  2. National Institutes of Health

    Bethesda, United States

    12 h-index

    32 publications

    3.6K citations

  3. Johns Hopkins University

    Baltimore, United States

    12 h-index

    35 publications

    3.3K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    11 h-index

    35 publications

    5.2K citations

  5. Guy's Hospital

    London, United Kingdom

    10 h-index

    26 publications

    2.1K citations

  6. Babraham Institute

    Cambridge, United Kingdom

    9 h-index

    19 publications

    7.7K citations

  7. Inserm

    Paris, France

    9 h-index

    36 publications

    1.2K citations

  8. Massachusetts General Hospital

    Boston, United States

    9 h-index

    22 publications

    2.1K citations

1–8 of 716

Venues

  1. Journal of Biological Chemistry

    JBC · 39 publications · 4K citations

    32

    h-index

  2. PubMed

    Repository · 49 publications · 1.8K citations

    24

    h-index

  3. Journal of Neurochemistry

    JNC · 25 publications · 1.4K citations

    21

    h-index

  4. Journal of Neuroscience

    21 publications · 2K citations

    20

    h-index

  5. Endocrinology

    29 publications · 1.5K citations

    20

    h-index

1–5