Concepedia

Sclerotome Specification

Sclerotome Specification is a developmental biology process that refers to the commitment of somitic mesoderm cells to a sclerotomal lineage through the activation of specific transcriptional regulators, notably Pax1 and Pax9, under the influence of inductive signals such as Shh from the notochord and floor plate, thereby distinguishing it from other somite-derived lineages like the dermomyotome.

67

Publications

7.5K

Citations

284

Authors

140

Institutions

Publications per year

2017–2026

6

Parents

Publications

67

The teratogenic <i>Veratrum</i> alkaloid cyclopamine inhibits Sonic hedgehog signal transduction

John P. Incardona, William Gaffield, Raj P. Kapur et al. · Development · 1998 · 651 citations

, , +17

Patterning of mammalian somites by surface ectoderm and notochord: Evidence for sclerotome induction by a hedgehog homolog

Chen‐Ming Fan, Marc Tessier‐Lavigne · Cell · 1994 · 592 citations

, , +15

The role of <i>Pax-1</i> in axial skeleton development

Johan Wallin, Jörg Wilting, Haruhiko Koseki et al. · Development · 1994 · 357 citations

, , +17

Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway

Chen‐Ming Fan, Jeffery A. Porter, Chin Chiang et al. · Cell · 1995 · 341 citations · Full text

, , +16

Pax1 and Pax9 synergistically regulate vertebral column development

Heiko Peters, Bettina Wilm, Norio Sakai et al. · Development · 1999 · 269 citations · Full text

, , +16

1–5 of 67

Authors

284

  1. RB
    Rudi Balling

    University of Luxembourg, Luxembourg

    7 publications · 1.2K citations

    7

    h-index

  2. RJ
    Roger J. Keynes

    University of Cambridge, United Kingdom

    6 publications · 550 citations

    6

    h-index

  3. KI
    Kenji Imai

    Gifu University, Japan

    5 publications · 586 citations

    5

    h-index

  4. CD
    Claudio D. Stern

    University College London, United Kingdom

    5 publications · 378 citations

    5

    h-index

  5. HK
    Haruhiko Koseki

    RIKEN Center for Integrative Medical Sciences, Japan

    5 publications · 772 citations

    5

    h-index

1–5 of 284

Institutions

140

  1. Max Planck Institute of Immunobiology and Epigenetics

    Freiburg, Germany

    5 h-index

    18 publications

    3.6K citations

  2. University of Cambridge

    Cambridge, United Kingdom

    5 h-index

    9 publications

    1K citations

  3. Institute of Groundwater Ecology

    Landau, Germany

    5 h-index

    20 publications

    2.2K citations

  4. University of California, San Francisco

    San Francisco, United States

    4 h-index

    9 publications

    2.1K citations

  5. University College London

    London, United Kingdom

    3 h-index

    12 publications

    868 citations

  6. University of Freiburg

    Freiburg im Breisgau, Germany

    3 h-index

    9 publications

    1.7K citations

  7. École Polytechnique Fédérale de Lausanne

    Lausanne, Switzerland

    3 h-index

    9 publications

    1K citations

  8. King's College London

    London, United Kingdom

    3 h-index

    12 publications

    435 citations

1–8 of 140

Venues

  1. Development

    28 publications · 4.4K citations

    27

    h-index

  2. Developmental Biology

    8 publications · 430 citations

    8

    h-index

  3. Developmental Dynamics

    6 publications · 224 citations

    6

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 313 citations

    3

    h-index

  5. genesis

    2 publications · 45 citations

    2

    h-index

1–5