Concepedia

Scale-down Models

Scale-Down Models is a systematic experimental framework belonging to the class of bioprocess modeling tools that, through the faithful miniaturization and dynamic simulation of large-scale bioreactor conditions, enables the prediction and analysis of performance variables in scaled-up systems while maintaining physiological relevance at reduced volumes.

96

Publications

4K

Citations

398

Authors

121

Institutions

Publications per year

2017–2026

36

Variants

Scale-down Model

Parents

Publications

96

Scale-down simulators for metabolic analysis of large-scale bioprocesses

Peter Neubauer, Stefan Junne · Current Opinion in Biotechnology · 2010 · 196 citations

, , +16

Advanced microscale bioreactor system: a representative scale-down model for bench-top bioreactors

Wei-Ting Hsu, Rigzen P. S. Aulakh, Donald L. Traul et al. · Cytotechnology · 2012 · 140 citations · Full text

, , +15

Regime analysis and scale-down: Tools to investigate the performance of bioreactors

A. P. J. Sweere, K. Ch. A. M. Luyben, N. W. F. Kossen · Enzyme and Microbial Technology · 1987 · 137 citations

, , +12

An industrial perspective on bioreactor scale‐down: What we can learn from combined large‐scale bioprocess and model fluid studies

Henk Noorman · Biotechnology Journal · 2011 · 124 citations

, , +15

Twenty‐four well plate miniature bioreactor system as a scale‐down model for cell culture process development

Aaron Chen, Rajesh Chitta, David W. Chang et al. · Biotechnology and Bioengineering · 2008 · 122 citations

, , +16

1–5 of 96

Authors

398

  1. HN
    Henk Noorman

    DSM (Netherlands), Netherlands

    6 publications · 454 citations

    6

    h-index

  2. PN
    Peter Neubauer

    Technische Universität Berlin, Germany

    5 publications · 326 citations

    5

    h-index

  3. FD
    Frank Delvigne

    Gembloux Agro-Bio Tech, Belgium

    5 publications · 210 citations

    5

    h-index

  4. MM
    Massimo Morbidelli

    ETH Zurich, Switzerland

    4 publications · 204 citations

    4

    h-index

  5. MH
    M. Hoare

    University College London, United Kingdom

    4 publications · 237 citations

    4

    h-index

1–5 of 398

Institutions

121

  1. University College London

    London, United Kingdom

    9 h-index

    28 publications

    1.1K citations

  2. Delft University of Technology

    Delft, The Netherlands

    8 h-index

    22 publications

    1.2K citations

  3. Biochemical Society

    London, United Kingdom

    7 h-index

    20 publications

    582 citations

  4. DSM (Netherlands)

    Heerlen, Netherlands

    6 h-index

    7 publications

    565 citations

  5. ETH Zurich

    Zurich, Switzerland

    6 h-index

    14 publications

    669 citations

  6. Biogen (United States)

    Cambridge, United States

    5 h-index

    19 publications

    856 citations

  7. Technische Universität Berlin

    Berlin, Germany

    5 h-index

    21 publications

    1K citations

  8. Technical University of Denmark

    Kongens Lyngby, Denmark

    4 h-index

    13 publications

    328 citations

1–8 of 121

Venues

  1. Biotechnology Progress

    12 publications · 608 citations

    12

    h-index

  2. Biotechnology and Bioengineering

    13 publications · 564 citations

    12

    h-index

  3. Biotechnology Journal

    4 publications · 228 citations

    4

    h-index

  4. Journal of Chromatography A

    4 publications · 142 citations

    4

    h-index

  5. 3

    h-index

1–5