Concepedia

Scaffold Simplification

Scaffold Simplification is a scaffold hopping strategy that reduces molecular complexity by retaining essential pharmacophoric features while removing or minimizing peripheral structural elements to yield a structurally less intricate core framework with preserved biological activity.

3

Publications

86

Citations

27

Authors

9

Institutions

Publications per year

2017–2026

1

Parents

Publications

3

Design and Syntheses of Anti-Tuberculosis Agents Inspired by BTZ043 Using a Scaffold Simplification Strategy

Rohit Tiwari, Ute Möllmann, Sang‐Hyun Cho et al. · ACS Medicinal Chemistry Letters · 2014 · 37 citations · Full text

, , +15

Scaffold Simplification Strategy Leads to a Novel Generation of Dual Human Immunodeficiency Virus and Enterovirus-A71 Entry Inhibitors

Belén Martínez-Gualda, Liang Sun, Olaia Martí‐Marí et al. · Journal of Medicinal Chemistry · 2019 · 27 citations · Full text

, , +17

Design, synthesis and initial biological evaluation of a novel pladienolide analog scaffold

Mahesh Kumar Gundluru, Alan Pourpak, Xiaoli Cui et al. · MedChemComm · 2011 · 22 citations

, , +17

Synthesis, Stereochemical Confirmation, and Derivatization of 12( <i>S</i> ),16ϵ‐Dihydroxycleroda‐3,13‐dien‐15,16‐olide, a Clerodane Diterpene That Sensitizes Methicillin‐Resistant <i>Staphylococcus aureus</i> to β‐Lactam Antibiotics

Michael J. Zeiler, Gina M. Connors, Greg M. Durling et al. · Angewandte Chemie International Edition · 2022 · 12 citations · Full text

, , +17

A focused library synthesis and cytotoxicity of quinones derived from the natural product bolinaquinone

Azadeh Ghods, Jayne Gilbert, Jennifer R. Baker et al. · Royal Society Open Science · 2018 · 11 citations · Full text

, , +13

1–5 of 3

Authors

27

  1. HL
    Hyunwook Lee

    Pennsylvania State University, United States

    1 publications · 27 citations

    1

    h-index

  2. BM
    Belén Martínez-Gualda

    Rega Institute for Medical Research, Belgium

    1 publications · 27 citations

    1

    h-index

  3. CM
    Carmen Mirabelli

    University of Michigan, United States

    1 publications · 27 citations

    1

    h-index

  4. FG
    Federico Gago

    Universidad de Alcalá, Spain

    1 publications · 27 citations

    1

    h-index

  5. RA
    Rana Abdelnabi

    Rega Institute for Medical Research, Belgium

    1 publications · 27 citations

    1

    h-index

1–5 of 27

Institutions

9

  1. Universidad de Alcalá

    Alcalá de Henares, Spain

    1 h-index

    1 publications

    27 citations

  2. Pennsylvania State University

    State College, United States

    1 h-index

    3 publications

    81 citations

  3. University of Illinois Chicago

    Chicago, United States

    1 h-index

    2 publications

    74 citations

  4. University of Notre Dame

    Notre Dame, United States

    1 h-index

    3 publications

    111 citations

  5. St. Jude Children's Research Hospital

    Memphis, United States

    1 h-index

    5 publications

    110 citations

  6. Rega Institute for Medical Research

    Leuven, Belgium

    1 h-index

    7 publications

    189 citations

  7. KU Leuven

    Leuven, Belgium

    1 h-index

    7 publications

    189 citations

  8. Instituto de Química Médica

    Madrid, Spain

    1 h-index

    5 publications

    135 citations

1–8 of 9

Venues

  1. Journal of Medicinal Chemistry

    1 publications · 27 citations

    1

    h-index

  2. MedChemComm

    1 publications · 22 citations

    1

    h-index

  3. ACS Medicinal Chemistry Letters

    1 publications · 37 citations

    1

    h-index

  4. Royal Society Open Science

    1 publications · 11 citations

  5. Angewandte Chemie International Edition

    1 publications · 12 citations

1–5