Concepedia

Sasp Modulation

SASP Modulation is a molecular intervention strategy that selectively alters the composition or intensity of the senescence-associated secretory phenotype to influence cellular communication and tissue microenvironment dynamics in radiation-induced senescence.

114

Publications

8.8K

Citations

979

Authors

340

Institutions

Publications per year

2017–2026

95

Parents

Publications

114

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

LaTonya J. Hickson, Larissa Prata, Shane A. Bobart et al. · EBioMedicine · 2019 · 1.3K citations · Full text

, , +17

BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance

Nilgun Tasdemir, Ana Banito, Jae‐Seok Roe et al. · Cancer Discovery · 2016 · 404 citations · Full text

, , +15

Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

Akiko Takahashi, Tze Mun Loo, Ryo Okada et al. · Nature Communications · 2018 · 351 citations · Full text

, , +11

Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence

Maria Grazia Vizioli, Tianhui Liu, Karl N. Miller et al. · Genes & Development · 2020 · 335 citations · Full text

, , +17

The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice

Qixia Xu, Qiang Fu, Zi Li et al. · Nature Metabolism · 2021 · 318 citations · Full text

, , +15

1–5 of 114

Authors

979

  1. JC
    Judith Campisi

    Buck Institute for Research on Aging, United States

    6 publications · 1K citations

    6

    h-index

  2. JL
    James L. Kirkland

    Mayo Clinic in Florida, United States

    4 publications · 1.8K citations

    4

    h-index

  3. YS
    Yu Sun

    Chinese Academy of Sciences, China

    4 publications · 630 citations

    4

    h-index

  4. SA
    Sheila A. Stewart

    Washington University in St. Louis, United States

    4 publications · 511 citations

    4

    h-index

  5. GD
    Giovanni Di Bernardo

    University of Campania "Luigi Vanvitelli", Italy

    3 publications · 98 citations

    3

    h-index

1–5 of 979

Institutions

340

  1. Buck Institute for Research on Aging

    Novato, United States

    7 h-index

    34 publications

    4.9K citations

  2. Lawrence Berkeley National Laboratory

    Berkeley, United States

    6 h-index

    6 publications

    1K citations

  3. The University of Texas MD Anderson Cancer Center

    Houston, United States

    4 h-index

    31 publications

    1.1K citations

  4. Harvard University

    Cambridge, United States

    4 h-index

    18 publications

    2.9K citations

  5. Heidelberg University

    Heidelberg, Germany

    4 h-index

    36 publications

    3.8K citations

  6. Mayo Clinic in Florida

    Jacksonville, United States

    4 h-index

    37 publications

    41.8K citations

  7. Heinrich Heine University Düsseldorf

    Düsseldorf, Germany

    4 h-index

    17 publications

    765 citations

  8. National Institutes of Health

    Bethesda, United States

    4 h-index

    23 publications

    1.6K citations

1–8 of 340

Venues

  1. Aging Cell

    7 publications · 556 citations

    7

    h-index

  2. International Journal of Molecular Sciences

    IJMS · 6 publications · 134 citations

    5

    h-index

  3. Aging

    4 publications · 248 citations

    4

    h-index

  4. Nature Communications

    4 publications · 621 citations

    4

    h-index

  5. Scientific Reports

    3 publications · 307 citations

    3

    h-index

1–5