Concepedia

Rotatable Bond Reduction

Rotatable Bond Reduction is a molecular optimization strategy within permeability enhancement that specifically diminishes the number of freely rotating single bonds in a compound to improve its membrane permeability and bioavailability.

9

Publications

8.7K

Citations

37

Authors

11

Institutions

Publications per year

2017–2026

2

Parents

Publications

9

Molecular Properties That Influence the Oral Bioavailability of Drug Candidates

Daniel F. Veber, Stephen R. Johnson, Hung‐Yuan Cheng et al. · Journal of Medicinal Chemistry · 2002 · 8.1K citations

, , +15

Design of Non-fused Ring Acceptors toward High-Performance, Stable, and Low-Cost Organic Photovoltaics

Qing Shen, Chengliang He, Shuixing Li et al. · Accounts of Materials Research · 2022 · 140 citations

, , +16

Rotaxane Formation under Thermodynamic Control

Stuart Cantrill, Stuart J. Rowan, J. Fraser Stoddart · Organic Letters · 1999 · 119 citations

, , +15

Thermodynamic Synthesis of Rotaxanes by Imine Exchange

Stuart J. Rowan, J. Fraser Stoddart · Organic Letters · 1999 · 80 citations

, , +8

Hydrogen bonding and rotation barriers: A comparison between MNDO and AM1 results

Giuseppe Buemi, Felice Zuccarello, Antonio Raudino · Journal of Molecular Structure THEOCHEM · 1988 · 61 citations

, , +15

1–5 of 9

Authors

37

  1. SJ
    Stuart J. Rowan

    Case Western Reserve University, United States

    2 publications · 199 citations

    2

    h-index

  2. JF
    J. Fraser Stoddart

    Northwestern University, United States

    2 publications · 199 citations

    2

    h-index

  3. MS
    Minmin Shi

    Zhejiang University, China

    1 publications · 140 citations

    1

    h-index

  4. YS
    Youval Shvo

    Tel Aviv University, Israel

    1 publications · 45 citations

    1

    h-index

  5. KF
    Kym F. Faull

    University of California, Los Angeles, United States

    1 publications · 34 citations

    1

    h-index

1–5 of 37

Institutions

11

  1. University of California, Los Angeles

    Los Angeles, United States

    3 h-index

    15 publications

    857 citations

  2. Neurobehavioral Systems

    Berkeley, United States

    1 h-index

    10 publications

    340 citations

  3. Princeton University

    Princeton, United States

    1 h-index

    2 publications

    90 citations

  4. Zhejiang University

    Hangzhou, China

    1 h-index

    6 publications

    840 citations

  5. University of Catania

    Catania, Italy

    1 h-index

    3 publications

    183 citations

  6. State Key Laboratory of Silicon Materials

    Hangzhou, China

    1 h-index

    6 publications

    840 citations

  7. Weizmann Institute of Science

    Rehovot, Israel

    1 h-index

    1 publications

    45 citations

  8. University of Oxford

    Oxford, United Kingdom

    1 h-index

    2 publications

    74 citations

1–8 of 11

Venues

  1. Organic Letters

    OL · 2 publications · 199 citations

    2

    h-index

  2. Journal of Medicinal Chemistry

    1 publications · 8.1K citations

    1

    h-index

  3. Journal of Molecular Structure THEOCHEM

    1 publications · 61 citations

    1

    h-index

  4. Tetrahedron Letters

    1 publications · 45 citations

    1

    h-index

  5. Molecules

    1 publications · 37 citations

    1

    h-index

1–5