Concepedia

Rotamer Optimization Algorithms

Rotamer Optimization Algorithms is a computational method in structural biology that determines the optimal side-chain conformations of amino acids in proteins by systematically sampling rotameric states and minimizing energy functions to achieve sterically favorable packing arrangements.

49

Publications

3.6K

Citations

150

Authors

71

Institutions

Publications per year

2017–2026

5

Parents

Publications

49

A New Approach to the Rapid Determination of Protein Side Chain Conformations

Pierre Tufféry, S. Hazout, Richard Lavery · Journal of Biomolecular Structure and Dynamics · 1991 · 349 citations

, , +17

De novo design of the hydrophobic cores of proteins

John R. Desjarlais, Tracy M. Handel · Protein Science · 1995 · 307 citations · Full text

, , +15

Efficient rotamer elimination applied to protein side-chains and related spin glasses

Robert F. Goldstein · Biophysical Journal · 1994 · 280 citations · Full text

, , +9

Exploring the conformational space of protein side chains using dead-end elimination and the A* algorithm

Andrew R. Leach, Andrew P. Lemon · Proteins Structure Function and Bioinformatics · 1998 · 224 citations

, , +16

Computational Design of a Single Amino Acid Sequence that Can Switch between Two Distinct Protein Folds

Xavier Ambroggio, Brian Kuhlman · Journal of the American Chemical Society · 2006 · 198 citations

, , +17

1–5 of 49

Authors

150

  1. SL
    Stephen L. Mayo

    California Institute of Technology, United States

    5 publications · 461 citations

    5

    h-index

  2. PT
    Pierre Tufféry

    Université Paris Cité, France

    3 publications · 433 citations

    3

    h-index

  3. RL
    Richard Lavery

    Institut de Biologie Physico-Chimique, France

    3 publications · 433 citations

    3

    h-index

  4. DB
    David B. Gordon

    Howard Hughes Medical Institute, United States

    2 publications · 215 citations

    2

    h-index

  5. GK
    Geoffrey K. Hom

    Howard Hughes Medical Institute, United States

    2 publications · 148 citations

    2

    h-index

1–5 of 150

Institutions

71

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    7 h-index

    8 publications

    516 citations

  2. California Institute of Technology

    Pasadena, United States

    6 h-index

    17 publications

    1.1K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    6 publications

    967 citations

  4. Laboratoire de Biochimie Théorique

    Paris, France

    3 h-index

    7 publications

    934 citations

  5. Institut de Biologie Physico-Chimique

    Paris, France

    3 h-index

    7 publications

    934 citations

  6. Cornell University

    Ithaca, United States

    2 h-index

    4 publications

    374 citations

  7. Princeton University

    Princeton, United States

    2 h-index

    5 publications

    333 citations

  8. University of Science and Technology of China

    Hefei, China

    2 h-index

    11 publications

    730 citations

1–8 of 71

Venues

  1. Journal of Computational Chemistry

    10 publications · 791 citations

    10

    h-index

  2. Bioinformatics

    5 publications · 239 citations

    5

    h-index

  3. Proteins Structure Function and Bioinformatics

    3 publications · 309 citations

    3

    h-index

  4. PLoS Computational Biology

    2 publications · 56 citations

    2

    h-index

  5. Biopolymers

    2 publications · 43 citations

    2

    h-index

1–5