Concepedia

Reference-free Deconvolution

Reference-Free Deconvolution is a computational approach in cell-type deconvolution that infers cell-type proportions from bulk gene expression data without relying on pre-existing reference profiles of pure cell types, distinguishing itself from reference-based methods by leveraging internal data structure or statistical assumptions to identify latent cellular signatures.

18

Publications

1.1K

Citations

118

Authors

79

Institutions

Publications per year

2017–2026

15

Parents

Publications

18

Reference-free deconvolution of DNA methylation data and mediation by cell composition effects

E. Andrés Houseman, Molly L. Kile, David C. Christiani et al. · BMC Bioinformatics · 2016 · 266 citations · Full text

, , +16

Reference-free cell type deconvolution of multi-cellular pixel-resolution spatially resolved transcriptomics data

Brendan Miller, Feiyang Huang, Lyla Atta et al. · Nature Communications · 2022 · 237 citations · Full text

, , +15

A reference profile-free deconvolution method to infer cancer cell-intrinsic subtypes and tumor-type-specific stromal profiles

Li Wang, Robert Sebra, John P. Sfakianos et al. · Genome Medicine · 2020 · 111 citations · Full text

, , +17

TOAST: improving reference-free cell composition estimation by cross-cell type differential analysis

Ziyi Li, Hao Wu · Genome biology · 2019 · 105 citations · Full text

, , +12

DNA methylation-based prediction of response to immune checkpoint inhibition in metastatic melanoma

Katharina Filipski, Michael Scherer, Kim Nikola Zeiner et al. · Journal for ImmunoTherapy of Cancer · 2021 · 82 citations · Full text

, , +17

1–5 of 18

Authors

118

  1. MS
    Michael Scherer

    Heidelberg University, Germany

    3 publications · 159 citations

    3

    h-index

  2. EA
    E. Andrés Houseman

    Harvard University, United States

    3 publications · 333 citations

    3

    h-index

  3. JF
    Jean Fan

    Harvard University, United States

    2 publications · 252 citations

    2

    h-index

  4. ML
    Molly L. Kile

    Oregon State University, United States

    2 publications · 292 citations

    2

    h-index

  5. JW
    Jörn Walter

    Saarland University, Germany

    2 publications · 118 citations

    2

    h-index

1–5 of 118

Institutions

79

  1. Dartmouth College

    Hanover, United States

    3 h-index

    5 publications

    364 citations

  2. Heidelberg University

    Heidelberg, Germany

    3 h-index

    9 publications

    513 citations

  3. German Cancer Research Center

    Heidelberg, Germany

    3 h-index

    9 publications

    513 citations

  4. Saarland University

    Saarbrücken, Germany

    3 h-index

    7 publications

    395 citations

  5. Emory University

    Atlanta, United States

    3 h-index

    7 publications

    368 citations

  6. Freie Universität Berlin

    Berlin, Germany

    2 h-index

    6 publications

    212 citations

  7. Epigenomics (Germany)

    Berlin, Germany

    2 h-index

    5 publications

    185 citations

  8. Harvard University

    Cambridge, United States

    2 h-index

    2 publications

    292 citations

1–8 of 79

Venues

  1. Genome biology

    2 publications · 128 citations

    2

    h-index

  2. BMC Bioinformatics

    2 publications · 307 citations

    2

    h-index

  3. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 2 publications · 41 citations

    2

    h-index

  4. Bioinformatics

    2 publications · 59 citations

    2

    h-index

  5. Briefings in Bioinformatics

    1 publications · 16 citations

    1

    h-index

1–5