Concepedia

Reference-based Deconvolution

Reference-Based Deconvolution is a computational approach in cell-type deconvolution that belongs to the class of methods requiring prior knowledge of cell-type-specific gene expression profiles, distinguished by its reliance on a pre-defined reference signature matrix to estimate the proportional contributions of distinct cell types within bulk tissue samples.

39

Publications

3.3K

Citations

159

Authors

99

Institutions

Publications per year

2017–2026

27

Parents

Publications

39

A comparison of reference-based algorithms for correcting cell-type heterogeneity in Epigenome-Wide Association Studies

Andrew E. Teschendorff, Charles E. Breeze, Shijie Zheng et al. · BMC Bioinformatics · 2017 · 625 citations · Full text

, , +17

An optimized library for reference-based deconvolution of whole-blood biospecimens assayed using the Illumina HumanMethylationEPIC BeadArray

Lucas A. Salas, Devin C. Koestler, Rondi A. Butler et al. · Genome biology · 2018 · 464 citations · Full text

, , +17

Estimation of immune cell content in tumour tissue using single-cell RNA-seq data

Max Schelker, Sonia Feau, Jinyan Du et al. · Nature Communications · 2017 · 345 citations · Full text

, , +17

Enhanced cell deconvolution of peripheral blood using DNA methylation for high-resolution immune profiling

Lucas A. Salas, Ze Zhang, Devin C. Koestler et al. · Nature Communications · 2022 · 277 citations · Full text

, , +16

Reference-free cell type deconvolution of multi-cellular pixel-resolution spatially resolved transcriptomics data

Brendan Miller, Feiyang Huang, Lyla Atta et al. · Nature Communications · 2022 · 237 citations · Full text

, , +15

1–5 of 39

Authors

159

  1. GA
    Gareth A. Morris

    University of Manchester, United Kingdom

    8 publications · 291 citations

    8

    h-index

  2. KT
    Karl T. Kelsey

    Brown University, United States

    5 publications · 1K citations

    5

    h-index

  3. LA
    Lucas A. Salas

    Dartmouth College, United States

    5 publications · 1K citations

    5

    h-index

  4. DC
    Devin C. Koestler

    University of Kansas Medical Center, United States

    5 publications · 1K citations

    5

    h-index

  5. BC
    Brock C. Christensen

    Dartmouth College, United States

    5 publications · 1K citations

    5

    h-index

1–5 of 159

Institutions

99

  1. University of Manchester

    Manchester, United Kingdom

    7 h-index

    18 publications

    789 citations

  2. Neurological Surgery

    Rockville Centre, United States

    5 h-index

    10 publications

    2.1K citations

  3. University of California, San Francisco

    San Francisco, United States

    5 h-index

    10 publications

    2.1K citations

  4. Brown University

    Providence, United States

    5 h-index

    8 publications

    1.8K citations

  5. Dartmouth College

    Hanover, United States

    5 h-index

    12 publications

    2.3K citations

  6. University of Kansas Medical Center

    Kansas City, United States

    5 h-index

    5 publications

    1K citations

  7. Humboldt-Universität zu Berlin

    Berlin, Germany

    3 h-index

    5 publications

    772 citations

  8. Johns Hopkins University

    Baltimore, United States

    3 h-index

    19 publications

    1.4K citations

1–8 of 99

Venues

  1. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 6 publications · 132 citations

    6

    h-index

  2. Magnetic Resonance in Chemistry

    MRC · 5 publications · 183 citations

    5

    h-index

  3. Nature Communications

    4 publications · 909 citations

    4

    h-index

  4. Briefings in Bioinformatics

    3 publications · 123 citations

    3

    h-index

  5. Journal of Magnetic Resonance

    JMR · 3 publications · 102 citations

    3

    h-index

1–5