Concepedia

Reduced Function Alleles

Reduced Function Alleles is a genetic variant within a drug-metabolizing enzyme gene that belongs to the class of allelic forms characterized by diminished enzymatic activity compared to the wild-type allele, resulting in altered pharmacokinetics and potential clinical implications for drug response.

91

Publications

9.7K

Citations

621

Authors

271

Institutions

Publications per year

2017–2026

23

Parents

Publications

91

Cytochrome P-450 Polymorphisms and Response to Clopidogrel

Jessica L. Mega, Sandra Close, Stephen D. Wiviott et al. · New England Journal of Medicine · 2008 · 2.5K citations · Full text

, , +17

Cytochrome P450 Genetic Polymorphisms and the Response to Prasugrel

Jessica L. Mega, Sandra Close, Stephen D. Wiviott et al. · Circulation · 2009 · 648 citations

, , +17

Effect of Genetic Variation in the Organic Cation Transporter 1, OCT1, on Metformin Pharmacokinetics

C. Randell Brown, R A Castro, RJ Shi et al. · Clinical Pharmacology & Therapeutics · 2007 · 467 citations

, , +15

The landscape of human STR variation

Thomas Willems, Melissa Gymrek, Gareth Highnam et al. · Genome Research · 2014 · 312 citations · Full text

, , +15

Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study

Tanja Dujić, Kaixin Zhou, Louise A. Donnelly et al. · Diabetes · 2014 · 287 citations

, , +15

1–5 of 91

Authors

621

  1. JL
    Jing Lin

    Wenzhou Medical University, China

    3 publications · 64 citations

    3

    h-index

  2. YT
    Yoshiyuki Tanaka

    Institute of Agrobiological Sciences, Japan

    3 publications · 71 citations

    3

    h-index

  3. TG
    Tanjuro Goto

    Okayama University, Japan

    3 publications · 71 citations

    3

    h-index

  4. RT
    Roger Tavendale

    Ninewells Hospital, United Kingdom

    3 publications · 500 citations

    3

    h-index

  5. CW
    Chun Wang

    Wenzhou Medical University, China

    3 publications · 64 citations

    3

    h-index

1–5 of 621

Institutions

271

  1. Massachusetts General Hospital

    Boston, United States

    5 h-index

    16 publications

    1.3K citations

  2. Harvard University

    Cambridge, United States

    5 h-index

    15 publications

    917 citations

  3. National Institutes of Health

    Bethesda, United States

    4 h-index

    29 publications

    1.8K citations

  4. Brigham and Women's Hospital

    Boston, United States

    3 h-index

    9 publications

    12.4K citations

  5. Ruian People's Hospital

    Wenzhou, China

    3 h-index

    9 publications

    202 citations

  6. University of Dundee

    Dundee, United Kingdom

    3 h-index

    20 publications

    3.3K citations

  7. Medical University of Vienna

    Vienna, Austria

    3 h-index

    8 publications

    274 citations

  8. Inserm

    Paris, France

    3 h-index

    30 publications

    1.8K citations

1–8 of 271

Venues

  1. Genetics

    9 publications · 530 citations

    9

    h-index

  2. Clinical Pharmacology & Therapeutics

    CPT · 7 publications · 1.3K citations

    7

    h-index

  3. Journal of Bacteriology

    JB · 4 publications · 201 citations

    4

    h-index

  4. Frontiers in Pharmacology

    3 publications · 178 citations

    3

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 596 citations

    3

    h-index

1–5