Concepedia

Receptor Cooperativity

Receptor Cooperativity is a theoretical construct in pharmacology that denotes the phenomenon wherein the binding of a ligand to one receptor subunit influences the affinity or activity of neighboring subunits within a multimeric receptor complex, thereby enabling allosteric communication and graded responses to ligand concentration.

62

Publications

4.9K

Citations

262

Authors

116

Institutions

Publications per year

2017–2026

9

Parents

Publications

62

Insulin interactions with its receptors: Experimental evidence for negative cooperativity

Pierre De Meyts, Jesse Roth, David M. Neville et al. · Biochemical and Biophysical Research Communications · 1973 · 723 citations

, , +16

Site-site interactions among insulin receptors. Characterization of the negative cooperativity.

A R Bainco, Jesse Roth · Journal of Biological Chemistry · 1976 · 604 citations · Full text

, , +17

Modeling the chemotactic response of <i>Escherichia coli</i> to time-varying stimuli

Yuhai Tu, Thomas Shimizu, Howard C. Berg · Proceedings of the National Academy of Sciences · 2008 · 290 citations · Full text

, , +16

Insulin binding to the human lymphocyte receptor. Evaluation of the negative cooperativity model.

R J Pollet, Mary L. Standaert, B.A. Haase · Journal of Biological Chemistry · 1977 · 205 citations · Full text

, , +14

β-Adrenergic receptors: Evidence for negative cooperativity

Lee E. Limbird, Pierre De Meyts, Robert J. Lefkowitz · Biochemical and Biophysical Research Communications · 1975 · 204 citations

, , +12

1–5 of 62

Authors

262

  1. AC
    Arthur Christopoulos

    Monash University, Australia

    3 publications · 158 citations

    3

    h-index

  2. KW
    Kevin W. Plaxco

    University of California, Santa Barbara, United States

    3 publications · 157 citations

    3

    h-index

  3. FR
    Francesco Ricci

    University of Rome Tor Vergata, Italy

    3 publications · 157 citations

    3

    h-index

  4. PD
    Pierre De Meyts

    Novo Nordisk (Denmark), Denmark

    2 publications · 927 citations

    2

    h-index

  5. MS
    Monica Skoge

    Princeton University, United States

    2 publications · 114 citations

    2

    h-index

1–5 of 262

Institutions

116

  1. University of Rome Tor Vergata

    Rome, Italy

    4 h-index

    6 publications

    244 citations

  2. University of California San Diego

    San Diego, United States

    4 h-index

    7 publications

    667 citations

  3. Monash University

    Melbourne, Australia

    3 h-index

    12 publications

    739 citations

  4. Princeton University

    Princeton, United States

    3 h-index

    4 publications

    270 citations

  5. Stanford University

    Stanford, United States

    3 h-index

    4 publications

    287 citations

  6. Chinese Academy of Sciences

    Beijing, China

    3 h-index

    10 publications

    864 citations

  7. Université de Montréal

    Montreal, Canada

    3 h-index

    3 publications

    193 citations

  8. University of California, Santa Barbara

    Santa Barbara, United States

    3 h-index

    7 publications

    317 citations

1–8 of 116

Venues

  1. Molecular Pharmacology

    5 publications · 419 citations

    5

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 465 citations

    4

    h-index

  3. Physical Review Letters

    PRL · 4 publications · 348 citations

    4

    h-index

  4. Biochemistry

    4 publications · 163 citations

    4

    h-index

  5. Journal of Biological Chemistry

    JBC · 3 publications · 880 citations

    3

    h-index

1–5