Concepedia

Read-through Therapy

Read-Through Therapy is a therapeutic strategy in molecular medicine that functions as a pharmacological intervention designed to induce ribosomal read-through of premature termination codons in mutant mRNA transcripts, thereby enabling the production of full-length functional proteins in genetic disorders such as Epidermolysis Bullosa.

22

Publications

1.2K

Citations

174

Authors

75

Institutions

Publications per year

2017–2026

12

Variants

Read-through PharmacotherapyStop-codon Read-through Therapy

Parents

Publications

22

Correction of ATM gene function by aminoglycoside-induced read-through of premature termination codons

Chih‐Hung Lai, Helen H. Chun, Shareef Nahas et al. · Proceedings of the National Academy of Sciences · 2004 · 161 citations · Full text

, , +13

A Lack of Premature Termination Codon Read-Through Efficacy of PTC124 (Ataluren) in a Diverse Array of Reporter Assays

Stuart P. McElroy, Toshifumi Nomura, Leah S. Torrie et al. · PLoS Biology · 2013 · 136 citations · Full text

, , +14

A comparative evaluation of NB30, NB54 and PTC124 in translational read‐through efficacy for treatment of an USH1C nonsense mutation

Tobias Goldmann, Nora Overlack, Fabian Möller et al. · EMBO Molecular Medicine · 2012 · 102 citations · Full text

, , +13

Social inequality in fetal growth: a comparative study of Denmark, Finland, Norway and Sweden in the period 1981–2000

Laust Hvas Mortensen, Finn Diderichsen, Annett Arntzen et al. · Journal of Epidemiology & Community Health · 2008 · 100 citations

, , +17

The Genetic Landscape of Dystrophin Mutations in Italy: A Nationwide Study

Marcella Neri, Rachele Rossi, Cecilia Trabanelli et al. · Frontiers in Genetics · 2020 · 84 citations · Full text

, , +16

1–5 of 22

Authors

174

  1. KN
    Kerstin Nagel‐Wolfrum

    Johannes Gutenberg University Mainz, Germany

    4 publications · 175 citations

    4

    h-index

  2. DM
    Dillon M. Voss

    Case Western Reserve University, United States

    2 publications · 50 citations

    2

    h-index

  3. LY
    Lucia Yang

    Cold Spring Harbor Laboratory, United States

    2 publications · 50 citations

    2

    h-index

  4. AR
    Adrian R. Krainer

    Cold Spring Harbor Laboratory, United States

    2 publications · 50 citations

    2

    h-index

  5. AS
    A. Samanta

    University Hospitals of Leicester NHS Trust, United Kingdom

    2 publications · 53 citations

    2

    h-index

1–5 of 174

Institutions

75

  1. Johannes Gutenberg University Mainz

    Mainz, Germany

    4 h-index

    13 publications

    820 citations

  2. Hadassah Medical Center

    Jerusalem, Israel

    3 h-index

    7 publications

    134 citations

  3. Stony Brook University

    Stony Brook, United States

    2 h-index

    8 publications

    200 citations

  4. Hebrew University of Jerusalem

    Jerusalem, Israel

    2 h-index

    6 publications

    79 citations

  5. Cold Spring Harbor Laboratory

    Cold Spring Harbor, United States

    2 h-index

    14 publications

    350 citations

  6. Technion – Israel Institute of Technology

    Haifa, Israel

    2 h-index

    4 publications

    246 citations

  7. University of California, Los Angeles

    Los Angeles, United States

    2 h-index

    16 publications

    1.7K citations

  8. Karolinska Institutet

    Stockholm, Sweden

    2 h-index

    7 publications

    1.1K citations

1–8 of 75

Venues

  1. International Journal of Molecular Sciences

    IJMS · 3 publications · 73 citations

    3

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 199 citations

    2

    h-index

  3. Clinical and Experimental Pediatrics

    CEP · 1 publications · 25 citations

    1

    h-index

  4. Preprints.org

    Repository · 1 publications · 13 citations

    1

    h-index

  5. PLoS Biology

    1 publications · 136 citations

    1

    h-index

1–5