Concepedia

Rb1 Alterations

RB1 Alterations is a molecular genetic aberration characterized by mutations or deletions in the RB1 tumor suppressor gene, leading to dysregulation of the cell cycle and implicated in the pathogenesis of Merkel Cell Carcinoma.

585

Publications

39.2K

Citations

4.7K

Authors

1.2K

Institutions

Publications per year

2017–2026

206

Variants

Rb1 Gene Alterations

Parents

Publications

585

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

Eva Y.-H.P. Lee, Chi-Yao Chang, Nanpin Hu et al. · Nature · 1992 · 1.3K citations

, , +13

Requirement for a functional Rb-1 gene in murine development

Alan R. Clarke, Els Robanus Maandag, M van Roon et al. · Nature · 1992 · 1K citations

, , +6

Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.

Srikumar Chellappan, Virginia B. Kraus, Burkhard Kröger et al. · Proceedings of the National Academy of Sciences · 1992 · 624 citations · Full text

, , +17

Small Cell and Large Cell Neuroendocrine Carcinomas of the Pancreas are Genetically Similar and Distinct From Well-differentiated Pancreatic Neuroendocrine Tumors

Shinichi Yachida, Efsevia Vakiani, Catherine M. White et al. · The American Journal of Surgical Pathology · 2012 · 541 citations

, , +17

A novel retinoblastoma therapy from genomic and epigenetic analyses

Jinghui Zhang, Claudia A. Benavente, Justina McEvoy et al. · Nature · 2012 · 513 citations · Full text

, , +17

1–5 of 585

Authors

4.7K

  1. BL
    Brenda L. Gallie

    University of Toronto, Canada

    22 publications · 3.3K citations

    19

    h-index

  2. DL
    Dietmar Lohmann

    Essen University Hospital, Germany

    19 publications · 1.6K citations

    15

    h-index

  3. FD
    François Doz

    Institut Curie, France

    10 publications · 771 citations

    10

    h-index

  4. DC
    David Cobrinik

    Children's Hospital of Los Angeles, United States

    10 publications · 626 citations

    10

    h-index

  5. DH
    David H. Abramson

    Memorial Sloan Kettering Cancer Center, United States

    10 publications · 356 citations

    10

    h-index

1–5 of 4.7K

Institutions

1.2K

  1. University of Toronto

    Toronto, Canada

    25 h-index

    82 publications

    8.5K citations

  2. Inserm

    Paris, France

    22 h-index

    114 publications

    7.3K citations

  3. Memorial Sloan Kettering Cancer Center

    New York, United States

    21 h-index

    226 publications

    22.5K citations

  4. Cornell University

    Ithaca, United States

    19 h-index

    84 publications

    10.7K citations

  5. Harvard University

    Cambridge, United States

    17 h-index

    85 publications

    9.5K citations

  6. University Health Network

    Toronto, Canada

    17 h-index

    62 publications

    11K citations

  7. Essen University Hospital

    Essen, Germany

    15 h-index

    55 publications

    4.8K citations

  8. Institut Curie

    Paris, France

    15 h-index

    165 publications

    15.2K citations

1–8 of 1.2K

Venues

  1. PubMed

    Repository · 45 publications · 2.4K citations

    27

    h-index

  2. Genes Chromosomes and Cancer

    16 publications · 798 citations

    15

    h-index

  3. Human Mutation

    15 publications · 1K citations

    14

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 13 publications · 2.3K citations

    13

    h-index

  5. Clinical Cancer Research

    13 publications · 1.4K citations

    13

    h-index

1–5