Concepedia

Ras Membrane Localization

RAS Membrane Localization is a molecular biological process that specifies the targeting and anchoring of RAS oncoproteins to the inner leaflet of the plasma membrane, mediated by post-translational modifications such as prenylation and palmitoylation, enabling their role in signal transduction.

260

Publications

26.5K

Citations

1.1K

Authors

312

Institutions

Publications per year

2017–2026

23

Variants

Ras Membrane Targeting

Parents

Publications

260

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

John F. Hancock, Hugh Paterson, Christopher J. Marshall · Cell · 1990 · 1.1K citations

, , +8

p21ras is modified by a farnesyl isoprenoid.

Patrick J. Casey, Patricia A. Solski, Channing J. Der et al. · Proceedings of the National Academy of Sciences · 1989 · 855 citations · Full text

, , +12

An Acylation Cycle Regulates Localization and Activity of Palmitoylated Ras Isoforms

Oliver Rocks, Anna Peyker, Martin Kahms et al. · Science · 2005 · 853 citations

, , +17

Endomembrane Trafficking of Ras

Edwin Choy, Vi K. Chiu, Joseph Silletti et al. · Cell · 1999 · 775 citations · Full text

, , +16

The p21 ras C-terminus is required for transformation and membrane association

Berthe M. Willumsen, Annette Christensen, N L Hubbert et al. · Nature · 1984 · 604 citations

, , +10

1–5 of 260

Authors

1.1K

  1. JF
    John F. Hancock

    The University of Queensland, Australia

    25 publications · 4K citations

    23

    h-index

  2. HW
    Herbert Waldmann

    Max Planck Institute of Molecular Physiology, Germany

    12 publications · 1.9K citations

    12

    h-index

  3. MR
    Mark R. Philips

    New York University, United States

    10 publications · 1.8K citations

    10

    h-index

  4. RJ
    Robert J. Deschenes

    University of Iowa, United States

    10 publications · 1.8K citations

    10

    h-index

  5. CJ
    Channing J. Der

    University of North Carolina at Chapel Hill, United States

    9 publications · 1.8K citations

    9

    h-index

1–5 of 1.1K

Institutions

312

  1. The University of Queensland

    Brisbane, Australia

    15 h-index

    44 publications

    6.7K citations

  2. Max Planck Institute of Molecular Physiology

    Dortmund, Germany

    15 h-index

    86 publications

    19.8K citations

  3. New York University

    New York, United States

    11 h-index

    46 publications

    10.6K citations

  4. The University of Texas Health Science Center at Houston

    Houston, United States

    11 h-index

    33 publications

    2.4K citations

  5. Tel Aviv University

    Tel Aviv, Israel

    10 h-index

    42 publications

    5.5K citations

  6. National Cancer Institute

    Bethesda, United States

    10 h-index

    30 publications

    4.7K citations

  7. University of Iowa

    Iowa City, United States

    9 h-index

    29 publications

    4.1K citations

  8. Consejo Superior de Investigaciones Científicas

    Madrid, Spain

    8 h-index

    28 publications

    2.1K citations

1–8 of 312

Venues

  1. Journal of Biological Chemistry

    JBC · 47 publications · 4.9K citations

    37

    h-index

  2. Molecular and Cellular Biology

    MCB · 29 publications · 3.2K citations

    27

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 14 publications · 3K citations

    14

    h-index

  4. PubMed

    Repository · 9 publications · 840 citations

    9

    h-index

  5. Biochemistry

    7 publications · 575 citations

    7

    h-index

1–5