Concepedia

Ras Effector Specificity

RAS Effector Specificity is a molecular oncology concept that denotes the selective activation of distinct downstream signaling pathways by RAS proteins through preferential engagement of specific effector proteins, thereby determining cellular outcomes in a context-dependent manner.

80

Publications

7.8K

Citations

400

Authors

145

Institutions

Publications per year

2017–2026

8

Parents

Publications

80

Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis

Elżbieta Janda, Kerstin Lehmann, Iris Killisch et al. · The Journal of Cell Biology · 2002 · 697 citations · Full text

, , +17

Phospholipase Cϵ: a novel Ras effector

Grant G. Kelley · The EMBO Journal · 2001 · 368 citations · Full text

, , +7

Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region.

Pizon, Pierre Teilhard de Chardin, I. Lerosey et al. · PubMed · 1988 · 337 citations

, , +7

Signaling Specificity by Ras Family GTPases Is Determined by the Full Spectrum of Effectors They Regulate

Pablo Rodriguez‐Viciana, Celine Sabatier, Frank McCormick · Molecular and Cellular Biology · 2004 · 332 citations · Full text

, , +15

Ras Pathway Specificity Is Determined by the Integration of Multiple Signal-Activated and Tissue-Restricted Transcription Factors

Marc S. Halfon, Ana Carmena, Stephen S. Gisselbrecht et al. · Cell · 2000 · 324 citations · Full text

, , +15

1–5 of 80

Authors

400

  1. CH
    Christian Herrmann

    Ruhr University Bochum, Germany

    7 publications · 671 citations

    7

    h-index

  2. CJ
    Channing J. Der

    University of North Carolina at Chapel Hill, United States

    4 publications · 289 citations

    4

    h-index

  3. TK
    Tohru Kataoka

    Kobe University, Japan

    4 publications · 241 citations

    4

    h-index

  4. FM
    Frank McCormick

    University of California, San Francisco, United States

    4 publications · 511 citations

    4

    h-index

  5. HR
    Hans Robert Kalbitzer

    University of Regensburg, Germany

    4 publications · 334 citations

    4

    h-index

1–5 of 400

Institutions

145

  1. National Cancer Institute

    Bethesda, United States

    7 h-index

    22 publications

    1.9K citations

  2. Max Planck Institute of Molecular Physiology

    Dortmund, Germany

    7 h-index

    25 publications

    2.6K citations

  3. Max Planck Society

    Munich, Germany

    6 h-index

    18 publications

    1.8K citations

  4. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    6 h-index

    16 publications

    1.5K citations

  5. National Institutes of Health

    Bethesda, United States

    4 h-index

    10 publications

    1K citations

  6. Cold Spring Harbor Laboratory

    Cold Spring Harbor, United States

    4 h-index

    9 publications

    672 citations

  7. Kobe University

    Kobe, Japan

    4 h-index

    29 publications

    1.8K citations

  8. University of Regensburg

    Regensburg, Germany

    4 h-index

    10 publications

    766 citations

1–8 of 145

Venues

  1. Journal of Biological Chemistry

    JBC · 18 publications · 1.8K citations

    17

    h-index

  2. PubMed

    Repository · 6 publications · 593 citations

    6

    h-index

  3. Molecular and Cellular Biology

    MCB · 5 publications · 617 citations

    5

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 829 citations

    4

    h-index

  5. The EMBO Journal

    4 publications · 689 citations

    4

    h-index

1–5