Concepedia

Random X Inactivation

Random X Inactivation is a genetic mechanism in female mammals whereby one of the two X chromosomes is transcriptionally silenced in a cell-specific manner during early embryonic development, with the choice of the inactivated X chromosome occurring randomly and independently in each cell, leading to a mosaic pattern of gene expression across tissues.

265

Publications

18.3K

Citations

1.2K

Authors

460

Institutions

Publications per year

2017–2026

34

Parents

Publications

265

Role of Histone H3 Lysine 27 Methylation in X Inactivation

Kathrin Plath, Jia Fang, Susanna Mlynarczyk‐Evans et al. · Science · 2003 · 1.2K citations

, , +17

Epigenetic Dynamics of Imprinted X Inactivation During Early Mouse Development

Ikuhiro Okamoto, Arie P. Otte, C. David Allis et al. · Science · 2003 · 817 citations

, , +17

Reactivation of the Paternal X Chromosome in Early Mouse Embryos

Winifred Mak, Tatyana B. Nesterova, Mariana de Napoles et al. · Science · 2004 · 545 citations

, , +16

Targeted Mutagenesis of Tsix Leads to Nonrandom X Inactivation

Jeannie T. Lee, Naifang Lu · Cell · 1999 · 514 citations · Full text

, , +8

GFAP promoter directs astrocyte-specific expression in transgenic mice

Michael Brenner, WC Kisseberth, Yuan Su et al. · Journal of Neuroscience · 1994 · 497 citations · Full text

, , +17

1–5 of 265

Authors

1.2K

  1. JG
    Joost Gribnau

    Erasmus MC, Netherlands

    7 publications · 556 citations

    7

    h-index

  2. NT
    Nobuo Takagi

    Hokkaido University, Japan

    6 publications · 378 citations

    6

    h-index

  3. ÉH
    Édith Heard

    Institut Curie, France

    6 publications · 1.1K citations

    6

    h-index

  4. BC
    B.M. Cattanach

    Mary Lyon Centre at MRC Harwell, United Kingdom

    5 publications · 438 citations

    5

    h-index

  5. NB
    Neil Brockdorff

    University of Oxford, United Kingdom

    5 publications · 830 citations

    5

    h-index

1–5 of 1.2K

Institutions

460

  1. Harvard University

    Cambridge, United States

    11 h-index

    32 publications

    4.4K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    10 h-index

    34 publications

    7.1K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    9 h-index

    31 publications

    5.2K citations

  4. Inserm

    Paris, France

    8 h-index

    24 publications

    1.3K citations

  5. Erasmus MC

    Rotterdam, The Netherlands

    7 h-index

    36 publications

    3.2K citations

  6. The University of Melbourne

    Melbourne, Australia

    7 h-index

    7 publications

    586 citations

  7. Hokkaido University

    Sapporo, Japan

    7 h-index

    15 publications

    876 citations

  8. Institut Curie

    Paris, France

    6 h-index

    25 publications

    5.4K citations

1–8 of 460

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 12 publications · 930 citations

    11

    h-index

  2. Genetics Research

    11 publications · 595 citations

    11

    h-index

  3. American Journal of Medical Genetics

    11 publications · 480 citations

    10

    h-index

  4. Development

    11 publications · 734 citations

    10

    h-index

  5. Human Genetics

    9 publications · 542 citations

    9

    h-index

1–5