Concepedia

Proteolysis Bias

Proteolysis Bias is a systematic error in bottom-up proteomics arising from the non-uniform cleavage of proteins during proteolytic digestion, leading to unequal representation of peptides and potentially skewed protein identification and quantification.

16

Publications

1K

Citations

73

Authors

35

Institutions

Publications per year

2017–2026

3

Variants

Proteolytic Bias

Parents

Publications

16

Quantitative Assessment of In-solution Digestion Efficiency Identifies Optimal Protocols for Unbiased Protein Analysis

Ileana R. León, Veit Schwämmle, Ole N. Jensen et al. · Molecular & Cellular Proteomics · 2013 · 261 citations · Full text

, , +17

The Implications of Proteolytic Background for Shotgun Proteomics

Paola Picotti, Ruedi Aebersold, Bruno Domon · Molecular & Cellular Proteomics · 2007 · 192 citations · Full text

, , +13

An Augmented Multiple-Protease-Based Human Phosphopeptide Atlas

Piero Giansanti, Thin Thin Aye, Henk van den Toorn et al. · Cell Reports · 2015 · 105 citations · Full text

, , +17

Are genuine changes in protein expression being overlooked? Reassessing Western blotting

Janelle P. Mollica, Jonathan S. Oakhill, Graham D. Lamb et al. · Analytical Biochemistry · 2009 · 82 citations

, , +13

The ClpP Peptidase Is the Major Determinant of Bulk Protein Turnover in <i>Bacillus subtilis</i>

Holger Kock, Ulf Gerth, Michael Hecker · Journal of Bacteriology · 2004 · 70 citations · Full text

, , +17

1–5 of 16

Authors

73

  1. RR
    Richard R. Sprenger

    University of Southern Denmark, Denmark

    2 publications · 274 citations

    2

    h-index

  2. LS
    Liangliang Sun

    Michigan State University, United States

    1 publications · 13 citations

    1

    h-index

  3. KP
    Kim Plasman

    Ghent University, Belgium

    1 publications · 38 citations

    1

    h-index

  4. SA
    Stefanie A.H. de Poot

    University Medical Center Utrecht, Netherlands

    1 publications · 38 citations

    1

    h-index

  5. LC
    Lulu Cao

    Brown University, United States

    1 publications · 26 citations

    1

    h-index

1–5 of 73

Institutions

35

  1. University of Zurich

    Zurich, Switzerland

    2 h-index

    2 publications

    258 citations

  2. University Medical Center Utrecht

    Utrecht, The Netherlands

    1 h-index

    4 publications

    152 citations

  3. National Taiwan Ocean University

    Keelung, Taiwan

    1 h-index

    2 publications

    78 citations

  4. SIB Swiss Institute of Bioinformatics

    Lausanne, Switzerland

    1 h-index

    7 publications

    238 citations

  5. VIB-UGent Center for Medical Biotechnology

    Ghent, Belgium

    1 h-index

    4 publications

    152 citations

  6. Universität Greifswald

    Greifswald, Germany

    1 h-index

    3 publications

    210 citations

  7. Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes

    Marseille, France

    1 h-index

    1 publications

    21 citations

  8. Michigan State University

    East Lansing, United States

    1 h-index

    2 publications

    26 citations

1–8 of 35

Venues

  1. Molecular & Cellular Proteomics

    MCP · 2 publications · 453 citations

    2

    h-index

  2. Analytical Chemistry

    1 publications · 23 citations

    2

    h-index

  3. 1

    h-index

  4. Journal of Proteome Research

    JPR · 1 publications · 34 citations

    1

    h-index

  5. The EMBO Journal

    1 publications · 39 citations

    1

    h-index

1–5