Concepedia

Protein Structure-function Analysis

Protein Structure-Function Analysis is a methodological framework in molecular biology that integrates structural and functional data to elucidate how the three-dimensional architecture of a protein determines its biochemical activity, distinguishing it from purely sequence- or activity-based analyses by explicitly correlating spatial features with mechanistic roles in biocatalyst discovery and site-directed mutagenesis.

1.3K

Publications

93.7K

Citations

6.5K

Authors

1.5K

Institutions

Publications per year

2017–2026

195

Parents

Publications

1.3K

I-TASSER server: new development for protein structure and function predictions

Jianyi Yang, Yang Zhang · Nucleic Acids Research · 2015 · 2.7K citations · Full text

, , +16

Primary structure of the Aequorea victoria green-fluorescent protein

Douglas C. Prasher, Virginia K. Eckenrode, William W. Ward et al. · Gene · 1992 · 2.2K citations

, , +14

CAVER 3.0: A Tool for the Analysis of Transport Pathways in Dynamic Protein Structures

Eva Chovancová, Antonín Pavelka, Petr Beneš et al. · PLoS Computational Biology · 2012 · 1.4K citations · Full text

, , +17

Principal Component Analysis: A Method for Determining the Essential Dynamics of Proteins

Charles David, Donald J. Jacobs · Methods in molecular biology · 2013 · 1.2K citations

, , +14

Protein structure analysis of mutations causing inheritable diseases. An e-Science approach with life scientist friendly interfaces

Hanka Venselaar, Tim AH te Beek, Remko Kuipers et al. · BMC Bioinformatics · 2010 · 1.2K citations · Full text

, , +16

1–5 of 1.3K

Authors

6.5K

  1. SS
    Stewart Shuman

    Kettering University, United States

    19 publications · 1.2K citations

    16

    h-index

  2. JM
    Janet M. Thornton

    University College London, United Kingdom

    6 publications · 1.5K citations

    6

    h-index

  3. YZ
    Yang Zhang

    University of Michigan, United States

    6 publications · 3K citations

    6

    h-index

  4. RA
    Roman A. Laskowski

    European Bioinformatics Institute, United Kingdom

    6 publications · 1.3K citations

    6

    h-index

  5. RB
    Russ B. Altman

    Stanford University, United States

    5 publications · 271 citations

    5

    h-index

1–5 of 6.5K

Institutions

1.5K

  1. Centre National de la Recherche Scientifique

    Paris, France

    29 h-index

    262 publications

    13.2K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    23 h-index

    83 publications

    11.3K citations

  3. National Institutes of Health

    Bethesda, United States

    21 h-index

    111 publications

    9.6K citations

  4. University of Michigan

    Ann Arbor, United States

    21 h-index

    90 publications

    10.1K citations

  5. Harvard University

    Cambridge, United States

    21 h-index

    69 publications

    7K citations

  6. Inserm

    Paris, France

    20 h-index

    77 publications

    4.7K citations

  7. University of Toronto

    Toronto, Canada

    20 h-index

    81 publications

    8.1K citations

  8. Kettering University

    Flint, United States

    17 h-index

    62 publications

    2.2K citations

1–8 of 1.5K

Venues

  1. Journal of Biological Chemistry

    JBC · 206 publications · 13.5K citations

    68

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 54 publications · 5.9K citations

    41

    h-index

  3. Nucleic Acids Research

    47 publications · 6.6K citations

    30

    h-index

  4. Biochemistry

    59 publications · 2.2K citations

    29

    h-index

  5. Molecular and Cellular Biology

    MCB · 35 publications · 2.9K citations

    26

    h-index

1–5