Concepedia

Protein Interface Specificity Engineering

Protein Interface Specificity Engineering is a methodological framework within protein-protein interaction engineering that enables the precise redesign of interfacial residues to confer selective binding affinity between target protein partners while minimizing off-target interactions.

7

Publications

442

Citations

58

Authors

20

Institutions

Publications per year

2017–2026

2

Parents

Publications

7

Design of Bioelectronic Interfaces by Exploiting Hinge-Bending Motions in Proteins

David E. Benson, David W. Conrad, Robert M. de et al. · Science · 2001 · 158 citations

, , +17

A Genetically Encoded aza-Michael Acceptor for Covalent Cross-Linking of Protein–Receptor Complexes

Jennifer L. Furman, Mingchao Kang, Seihyun Choi et al. · Journal of the American Chemical Society · 2014 · 109 citations · Full text

, , +17

Computational Redesign of a Protein–Protein Interface for High Affinity and Binding Specificity Using Modular Architecture and Naturally Occurring Template Fragments

Vladimir Potapov, Dana Reichmann, Renne Abramovich et al. · Journal of Molecular Biology · 2008 · 49 citations

, , +17

“Silent” Amino Acid Residues at Key Subunit Interfaces Regulate the Geometry of Protein Nanocages

Shengli Zhang, Jiachen Zang, Xiaorong Zhang et al. · ACS Nano · 2016 · 43 citations

, , +15

Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules

Charlotte Rimbault, Kashyap Maruthi, Christelle Breillat et al. · Nature Communications · 2019 · 38 citations · Full text

, , +17

1–5 of 7

Authors

58

  1. DW
    David W. Conrad

    United States Naval Research Laboratory, United States

    1 publications · 158 citations

    1

    h-index

  2. BD
    Benjamin Dartigues

    Université de Bordeaux, France

    1 publications · 38 citations

    1

    h-index

  3. SP
    Steven P. Angus

    University of North Carolina at Chapel Hill, United States

    1 publications · 10 citations

    1

    h-index

  4. HC
    Hai Chen

    Southwest University, China

    1 publications · 43 citations

    1

    h-index

  5. FW
    Fabienne Wong Jun Tai

    Inserm, France

    1 publications · 38 citations

    1

    h-index

1–5 of 58

Institutions

20

  1. Duke University Hospital

    Durham, United States

    1 h-index

    4 publications

    632 citations

  2. Institut Interdisciplinaire de Neuroscience

    Bordeaux, France

    1 h-index

    12 publications

    456 citations

  3. Weizmann Institute of Science

    Rehovot, Israel

    1 h-index

    9 publications

    441 citations

  4. Torrey Pines Institute For Molecular Studies

    San Diego, United States

    1 h-index

    4 publications

    436 citations

  5. China Agricultural University

    Beijing, China

    1 h-index

    5 publications

    215 citations

  6. Institute of Molecular Biology and Genetics

    Kyiv, Ukraine

    1 h-index

    5 publications

    175 citations

  7. Kyoto University

    Kyoto, Japan

    1 h-index

    2 publications

    86 citations

  8. Bordeaux Population Health

    Bordeaux, France

    1 h-index

    2 publications

    76 citations

1–8 of 20

Venues

  1. ACS Nano

    1 publications · 43 citations

    1

    h-index

  2. Science

    1 publications · 158 citations

    1

    h-index

  3. Journal of the American Chemical Society

    JACS · 1 publications · 109 citations

    1

    h-index

  4. Journal of Molecular Biology

    JMB · 1 publications · 49 citations

    1

    h-index

  5. Biochemical and Biophysical Research Communications

    BBRC · 1 publications · 35 citations

    1

    h-index

1–5