Concepedia

Protein Functional Design

Protein Functional Design is a type of protein engineering approach that specifically focuses on creating proteins with novel or enhanced biological functions by rationally designing amino acid sequences to achieve targeted functional properties, distinguishing it from structure-focused design methodologies.

116

Publications

7.5K

Citations

614

Authors

191

Institutions

Publications per year

2017–2026

39

Parents

Publications

116

Design and synthesis of multi-haem proteins

Dan E. Robertson, Ramy Farid, Christopher C. Moser et al. · Nature · 1994 · 571 citations

, , +12

Combinatorial Cassette Mutagenesis as a Probe of the Informational Content of Protein Sequences

John F. Reidhaar-Olson, Robert T. Sauer · Science · 1988 · 332 citations

, , +16

Design and Chemical Synthesis of a Homogeneous Polymer-Modified Erythropoiesis Protein

Gerd G. Kochendoerfer, Shiah-Yun Chen, Feng Mao et al. · Science · 2003 · 312 citations

, , +16

Design, synthesis, and application of a Protein A mimetic

Rongxiu Li, V. Dowd, David J. Stewart et al. · Nature Biotechnology · 1998 · 297 citations

, , +12

Machine learning for functional protein design

Pascal Notin, Nathan Rollins, Yarin Gal et al. · Nature Biotechnology · 2024 · 240 citations · Full text

, , +10

1–5 of 116

Authors

614

  1. DB
    David Baker

    University of Washington, United States

    4 publications · 302 citations

    4

    h-index

  2. BE
    Bruno E. Correia

    École Polytechnique Fédérale de Lausanne, Switzerland

    4 publications · 371 citations

    4

    h-index

  3. SG
    Sandrine Georgeon

    École Polytechnique Fédérale de Lausanne, Switzerland

    3 publications · 326 citations

    3

    h-index

  4. SR
    Stéphane Rosset

    University of Geneva, Switzerland

    3 publications · 262 citations

    3

    h-index

  5. XL
    Xinting Li

    University of Washington, United States

    3 publications · 178 citations

    3

    h-index

1–5 of 614

Institutions

191

  1. University of Washington

    Seattle, United States

    8 h-index

    44 publications

    2.6K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    5 h-index

    7 publications

    390 citations

  3. École Polytechnique Fédérale de Lausanne

    Lausanne, Switzerland

    4 h-index

    42 publications

    3.8K citations

  4. SIB Swiss Institute of Bioinformatics

    Lausanne, Switzerland

    4 h-index

    39 publications

    3.4K citations

  5. Massachusetts Institute of Technology

    Cambridge, United States

    3 h-index

    6 publications

    1.1K citations

  6. Heidelberg University

    Heidelberg, Germany

    3 h-index

    21 publications

    667 citations

  7. PDL BioPharma (United States)

    Incline Village, United States

    3 h-index

    4 publications

    152 citations

  8. Indian Institute of Science Bangalore

    Bengaluru, India

    3 h-index

    3 publications

    291 citations

1–8 of 191

Venues

  1. Journal of the American Chemical Society

    JACS · 8 publications · 715 citations

    8

    h-index

  2. Nature

    5 publications · 900 citations

    5

    h-index

  3. Science

    3 publications · 662 citations

    3

    h-index

  4. Angewandte Chemie International Edition

    3 publications · 189 citations

    3

    h-index

  5. Nature Biotechnology

    3 publications · 641 citations

    3

    h-index

1–5