Concepedia

Protein Function Conservation

Protein Function Conservation is the evolutionary phenomenon in which the biological function of a protein remains preserved across diverse species or homologous sequences despite sequence divergence, serving as a foundational principle for inferring functional annotations of uncharacterized proteins based on structurally or evolutionarily related counterparts.

74

Publications

8.3K

Citations

282

Authors

125

Institutions

Publications per year

2017–2026

7

Parents

Publications

74

Assigning protein functions by comparative genome analysis: Protein phylogenetic profiles

Matteo Pellegrini, Edward M. Marcotte, Michael J. Thompson et al. · Proceedings of the National Academy of Sciences · 1999 · 1.6K citations · Full text

, , +17

ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structures

Meytal Landau, Itay Mayrose, Y. Rosenberg et al. · Nucleic Acids Research · 2005 · 1.5K citations · Full text

, , +12

Predicting functionally important residues from sequence conservation

John A. Capra, Mona Singh · Bioinformatics · 2007 · 741 citations

, , +12

Phylogenetic and Functional Assessment of Orthologs Inference Projects and Methods

Adrian Altenhoff, Christophe Dessimoz · PLoS Computational Biology · 2009 · 438 citations · Full text

, , +17

How Well is Enzyme Function Conserved as a Function of Pairwise Sequence Identity?

Weidong Tian, Jeffrey Skolnick · Journal of Molecular Biology · 2003 · 427 citations

, , +12

1–5 of 74

Authors

282

  1. JS
    Jeffrey Skolnick

    Georgia Institute of Technology, United States

    2 publications · 482 citations

    2

    h-index

  2. LJ
    Lars Juhl Jensen

    University of Copenhagen, Denmark

    2 publications · 326 citations

    2

    h-index

  3. CR
    Christian R. Landry

    Université Laval, Canada

    2 publications · 147 citations

    2

    h-index

  4. HM
    Hanah Margalit

    Hebrew University of Jerusalem, Israel

    1 publications · 71 citations

    1

    h-index

  5. ME
    Michael E. Baker

    University of California San Diego, United States

    1 publications · 23 citations

    1

    h-index

1–5 of 282

Institutions

125

  1. National Institutes of Health

    Bethesda, United States

    3 h-index

    6 publications

    551 citations

  2. Hebrew University of Jerusalem

    Jerusalem, Israel

    3 h-index

    4 publications

    260 citations

  3. Harvard University

    Cambridge, United States

    2 h-index

    5 publications

    136 citations

  4. Medical College of Wisconsin

    Milwaukee, United States

    2 h-index

    3 publications

    156 citations

  5. Max Planck Society

    Munich, Germany

    2 h-index

    5 publications

    196 citations

  6. National Institute of Diabetes and Digestive and Kidney Diseases

    Bethesda, United States

    2 h-index

    3 publications

    398 citations

  7. Howard Hughes Medical Institute

    Chevy Chase, United States

    2 h-index

    4 publications

    562 citations

  8. University of California San Diego

    San Diego, United States

    2 h-index

    2 publications

    37 citations

1–8 of 125

Venues

  1. Nucleic Acids Research

    5 publications · 1.6K citations

    5

    h-index

  2. Bioinformatics

    5 publications · 858 citations

    5

    h-index

  3. PLoS Computational Biology

    4 publications · 516 citations

    4

    h-index

  4. Protein Science

    PS · 3 publications · 175 citations

    3

    h-index

  5. PubMed

    Repository · 3 publications · 62 citations

    3

    h-index

1–5