Concepedia

Protein Fold Engineering

Protein Fold Engineering is a computational and experimental methodology within protein engineering that specifically focuses on the rational design or directed evolution of the three-dimensional scaffold of a protein, distinguishing it from other approaches by targeting the fundamental architecture responsible for structural stability and functional topology rather than localized active sites or surface properties.

117

Publications

6.5K

Citations

601

Authors

221

Institutions

Publications per year

2017–2026

29

Parents

Publications

117

Protein Design by Binary Patterning of Polar and Nonpolar Amino Acids

Satwik Kamtekar, Jarad Schiffer, Huayu Xiong et al. · Science · 1993 · 744 citations

, , +17

Network of coupled promoting motions in enzyme catalysis

Pratul K. Agarwal, Salomon R. Billeter, P. T. Ravi Rajagopalan et al. · Proceedings of the National Academy of Sciences · 2002 · 462 citations · Full text

, , +17

The non‐enzymatic microbicidal activity of lysozymes

Klaus Düring, Petra Porsch, Andreas Mahn et al. · FEBS Letters · 1999 · 288 citations · Full text

, , +13

Stabilization of short collagen-like triple helices by protein engineering

Sabine Frank, Richard A. Kammerer, Diane E. Mechling et al. · Journal of Molecular Biology · 2001 · 209 citations

, , +12

A productive NADP+ binding mode of ferredoxin-NADP + reductase revealed by protein engineering and crystallographic studies.

P. Andrew Karplus, Zhan Deng, Alessandro Aliverti et al. · Nature Structural Biology · 1999 · 201 citations

, , +13

1–5 of 117

Authors

601

  1. MC
    M.P. Coles

    Max Planck Institute for Developmental Biology, Germany

    4 publications · 87 citations

    4

    h-index

  2. AN
    Andrei N. Lupas

    Max Planck Institute for Developmental Biology, Germany

    3 publications · 41 citations

    3

    h-index

  3. SN
    Stewart N. Loh

    SUNY Upstate Medical University, United States

    3 publications · 81 citations

    3

    h-index

  4. ME
    Mohammad ElGamacy

    Max Planck Institute for Developmental Biology, Germany

    3 publications · 41 citations

    3

    h-index

  5. WS
    W. Seth Horne

    University of Pittsburgh, United States

    3 publications · 127 citations

    3

    h-index

1–5 of 601

Institutions

221

  1. Max Planck Institute for Developmental Biology

    Tübingen, Germany

    4 h-index

    16 publications

    416 citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    4 h-index

    18 publications

    278 citations

  3. University of Washington

    Seattle, United States

    4 h-index

    16 publications

    693 citations

  4. SUNY Upstate Medical University

    Syracuse, United States

    3 h-index

    12 publications

    312 citations

  5. Princeton University

    Princeton, United States

    3 h-index

    16 publications

    4.4K citations

  6. KU Leuven

    Leuven, Belgium

    3 h-index

    9 publications

    430 citations

  7. University of California, San Francisco

    San Francisco, United States

    3 h-index

    8 publications

    538 citations

  8. Yale University

    New Haven, United States

    3 h-index

    15 publications

    1.1K citations

1–8 of 221

Venues

  1. Journal of Molecular Biology

    JMB · 11 publications · 794 citations

    11

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 9 publications · 925 citations

    9

    h-index

  3. Journal of the American Chemical Society

    JACS · 6 publications · 354 citations

    6

    h-index

  4. Protein Science

    PS · 6 publications · 319 citations

    6

    h-index

  5. Protein Engineering Design and Selection

    PEDS · 5 publications · 203 citations

    5

    h-index

1–5