Concepedia

Protein Binding Variability

Protein Binding Variability is the interindividual variation in the extent to which a drug binds to plasma proteins, primarily attributable to differences in protein concentrations, genetic polymorphisms, or physiological states that influence the fraction of unbound, pharmacologically active drug in circulation.

89

Publications

3.7K

Citations

323

Authors

131

Institutions

Publications per year

2017–2026

6

Variants

Variability In Protein Binding

Parents

Children

Publications

89

Resonance Raman investigations of site-directed mutants of myoglobin: effects of distal histidine replacement

Dimitrios Morikis, P. M. Champion, Barry A. Springer et al. · Biochemistry · 1989 · 199 citations

, , +10

The plasma protein binding of basic drugs.

PA Routledge · British Journal of Clinical Pharmacology · 1986 · 181 citations · Full text

, , +17

Lidocaine plasma protein binding

PA Routledge, Aaron Barchowsky, T D Bjornsson et al. · Clinical Pharmacology & Therapeutics · 1980 · 164 citations

, , +12

Structural variation in the antithrombin III binding site region and its occurrence in heparin from different sources

Duraikkannu Loganathan, Hui M. Wang, Larry M. Mallis et al. · Biochemistry · 1990 · 133 citations

, , +10

Factors affecting variability in distribution of tacrolimus in liver transplant recipients

Hamim Zahir, Geoffrey W. McCaughan, M. H. Gleeson et al. · British Journal of Clinical Pharmacology · 2004 · 115 citations · Full text

, , +17

1–5 of 89

Authors

323

  1. DJ
    David J. Greenblatt

    Tufts University, United States

    3 publications · 48 citations

    3

    h-index

  2. PR
    PA Routledge

    University Hospital Llandough, United Kingdom

    3 publications · 357 citations

    3

    h-index

  3. AY
    Avraham Yacobi

    University at Buffalo, State University of New York, United States

    3 publications · 71 citations

    3

    h-index

  4. GL
    Gerhard Levy

    University at Buffalo, State University of New York, United States

    3 publications · 79 citations

    3

    h-index

  5. AJ
    Andrew J. McLachlan

    The University of Sydney, Australia

    2 publications · 215 citations

    2

    h-index

1–5 of 323

Institutions

131

  1. University at Buffalo, State University of New York

    Buffalo, United States

    5 h-index

    11 publications

    345 citations

  2. University of Tennessee Health Science Center

    Memphis, United States

    3 h-index

    11 publications

    219 citations

  3. Karolinska Institutet

    Stockholm, Sweden

    3 h-index

    8 publications

    441 citations

  4. Massachusetts General Hospital

    Boston, United States

    3 h-index

    7 publications

    116 citations

  5. University of Oxford

    Oxford, United Kingdom

    2 h-index

    8 publications

    148 citations

  6. Tufts Medical Center

    Boston, United States

    2 h-index

    4 publications

    68 citations

  7. University of Tennessee at Knoxville

    Knoxville, United States

    2 h-index

    2 publications

    43 citations

  8. The University of Sydney

    Sydney, Australia

    2 h-index

    8 publications

    845 citations

1–8 of 131

Venues

  1. British Journal of Clinical Pharmacology

    BJCP · 7 publications · 520 citations

    7

    h-index

  2. Clinical Pharmacology & Therapeutics

    CPT · 6 publications · 366 citations

    6

    h-index

  3. Journal of Pharmaceutical Sciences

    6 publications · 177 citations

    5

    h-index

  4. Therapeutic Drug Monitoring

    5 publications · 126 citations

    5

    h-index

  5. European Journal of Clinical Pharmacology

    5 publications · 175 citations

    5

    h-index

1–5