Concepedia

Disease-related Binding Changes

Disease-Related Binding Changes is a biochemical phenomenon characterized by alterations in protein-ligand interaction affinities or specificities that arise as a direct consequence of pathological conditions, distinguishing it from binding variations due to non-disease factors.

27

Publications

2.2K

Citations

209

Authors

86

Institutions

Publications per year

2017–2026

8

Parents

Publications

27

Widespread Macromolecular Interaction Perturbations in Human Genetic Disorders

Nidhi Sahni, S. Stephen Yi, Mikko Taipale et al. · Cell · 2015 · 643 citations · Full text

, , +14

The Clinical Relevance of Plasma Protein Binding Changes

Jason A. Roberts, Federico Pea, Jeffrey Lipman · Clinical Pharmacokinetics · 2012 · 325 citations · Full text

, , +14

Comprehensive characterization of protein–protein interactions perturbed by disease mutations

Feixiong Cheng, Junfei Zhao, Yang Wang et al. · Nature Genetics · 2021 · 248 citations · Full text

, , +16

RNA binding proteins co-localize with small tau inclusions in tauopathy

Brandon F. Maziuk, Daniel J. Apicco, Anna Lourdes Cruz et al. · Acta Neuropathologica Communications · 2018 · 154 citations · Full text

, , +17

Cholinergic Receptors in Cognitive Disorders

Elaine K. Perry, Robert H. Perry, C.J. Smith et al. · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · 1986 · 149 citations · Full text

, , +17

1–5 of 27

Authors

209

  1. MV
    Marc Vidal

    Dana-Farber Cancer Institute, United States

    2 publications · 891 citations

    2

    h-index

  2. DE
    David E. Hill

    Harvard University, United States

    2 publications · 891 citations

    2

    h-index

  3. TH
    Tong Hao

    Harvard University, United States

    2 publications · 891 citations

    2

    h-index

  4. IK
    Irina Krykbaeva

    Whitehead Institute for Biomedical Research, United States

    1 publications · 643 citations

    1

    h-index

  5. LU
    Lea Ueberham

    Helmholtz-Zentrum Dresden-Rossendorf, Germany

    1 publications · 15 citations

    1

    h-index

1–5 of 209

Institutions

86

  1. Harvard University

    Cambridge, United States

    4 h-index

    40 publications

    18.9K citations

  2. Brigham and Women's Hospital

    Boston, United States

    3 h-index

    10 publications

    2.9K citations

  3. University of Massachusetts Chan Medical School

    Worcester, United States

    3 h-index

    6 publications

    1.5K citations

  4. University of Cambridge

    Cambridge, United Kingdom

    2 h-index

    4 publications

    248 citations

  5. Massachusetts Institute of Technology

    Cambridge, United States

    2 h-index

    8 publications

    3.9K citations

  6. Inserm

    Paris, France

    2 h-index

    10 publications

    106 citations

  7. Dana-Farber Cancer Institute

    Boston, United States

    2 h-index

    39 publications

    22.7K citations

  8. Cleveland Clinic

    Cleveland, United States

    1 h-index

    1 publications

    248 citations

1–8 of 86

Venues

  1. Cell

    1 publications · 643 citations

    1

    h-index

  2. Journal of Cerebral Blood Flow & Metabolism

    1 publications · 75 citations

    1

    h-index

  3. Psychopharmacology

    1 publications · 27 citations

    1

    h-index

  4. Biophysical Journal

    1 publications · 78 citations

    1

    h-index

  5. Biochemistry

    1 publications · 25 citations

    1

    h-index

1–5