Concepedia

Protein Binding Affinity

Protein Binding Affinity is a quantitative measure of the strength of interaction between a protein and its binding partner, distinguishing it from other binding characteristics by specifically reflecting the equilibrium association or dissociation constant of the molecular complex.

1.4K

Publications

76K

Citations

6.4K

Authors

1.5K

Institutions

Publications per year

2017–2026

275

Parents

Publications

1.4K

Regulation of protein-ligand binding affinity by hydrogen bond pairing

Deliang Chen, Numan Oezguen, Petri Urvil et al. · Science Advances · 2016 · 918 citations · Full text

, , +17

Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus

Barry J. Hartman, Alexander Tomasz · Journal of Bacteriology · 1984 · 882 citations · Full text

, , +17

A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits

David H. Presky, Hong Yang, Lisa J. Minetti et al. · Proceedings of the National Academy of Sciences · 1996 · 688 citations · Full text

, , +10

High and low affinity binding sites for basic fibroblast growth factor on cultured cells: Absence of a role for low affinity binding in the stimulation of plasminogen activator production by bovine capillary endothelial cells

David Moscatelli · Journal of Cellular Physiology · 1987 · 651 citations

, , +10

DeepAffinity: interpretable deep learning of compound–protein affinity through unified recurrent and convolutional neural networks

Mostafa Karimi, Di Wu, Zhangyang Wang et al. · Bioinformatics · 2019 · 531 citations · Full text

, , +16

1–5 of 1.4K

Authors

6.4K

  1. PS
    Peter Schuck

    National Institutes of Health, United States

    6 publications · 237 citations

    6

    h-index

  2. WH
    Walter Heyns

    KU Leuven, Belgium

    6 publications · 327 citations

    6

    h-index

  3. HZ
    Huaying Zhao

    National Institute of Biomedical Imaging and Bioengineering, United States

    5 publications · 154 citations

    5

    h-index

  4. SA
    Stephen Albert Johnston

    The University of Texas Southwestern Medical Center, United States

    4 publications · 175 citations

    4

    h-index

  5. VT
    Vladimir Tolmachev

    Uppsala University, Sweden

    4 publications · 167 citations

    4

    h-index

1–5 of 6.4K

Institutions

1.5K

  1. National Institutes of Health

    Bethesda, United States

    26 h-index

    110 publications

    8K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    23 h-index

    105 publications

    5.3K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    22 h-index

    85 publications

    9.2K citations

  4. Harvard University

    Cambridge, United States

    18 h-index

    62 publications

    7.4K citations

  5. University of California San Diego

    San Diego, United States

    17 h-index

    42 publications

    5.1K citations

  6. Inserm

    Paris, France

    15 h-index

    59 publications

    2.2K citations

  7. Massachusetts Institute of Technology

    Cambridge, United States

    13 h-index

    30 publications

    3K citations

  8. KTH Royal Institute of Technology

    Stockholm, Sweden

    13 h-index

    47 publications

    1.4K citations

1–8 of 1.5K

Venues

  1. Journal of Biological Chemistry

    JBC · 141 publications · 10.2K citations

    63

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 46 publications · 5K citations

    36

    h-index

  3. Biochemistry

    60 publications · 2.4K citations

    30

    h-index

  4. Journal of the American Chemical Society

    JACS · 26 publications · 1.7K citations

    24

    h-index

  5. Biochemical Journal

    BJ · 31 publications · 1.4K citations

    22

    h-index

1–5