Concepedia

Protein Binding Adjustment

Protein Binding Adjustment is a methodological framework in pharmacokinetics that adjusts drug concentration measurements to account for the fraction of drug bound to plasma proteins, thereby enabling accurate interpretation of the therapeutically active free drug fraction within the therapeutic range.

10

Publications

897

Citations

59

Authors

21

Institutions

Publications per year

2017–2026

2

Parents

Publications

10

Albumin Binding as a General Strategy for Improving the Pharmacokinetics of Proteins

Mark S. Dennis, Min Zhang, Miryam Kadkhodayan et al. · Journal of Biological Chemistry · 2002 · 498 citations · Full text

, , +13

Impact of pH on Plasma Protein Binding in Equilibrium Dialysis

Christopher J. Kochansky, Daniel R. McMasters, Ping Lü et al. · Molecular Pharmaceutics · 2008 · 87 citations

, , +17

Pharmacokinetic Modeling and Simulations of Interaction of Amprenavir and Ritonavir

Mark Sale, Brian M. Sadler, Daniel S. Stein · Antimicrobial Agents and Chemotherapy · 2002 · 57 citations · Full text

, , +17

Novel Method To Assess Antiretroviral Target Trough Concentrations Using<i>In Vitro</i>Susceptibility Data

Edward P. Acosta, Kay Limoli, Lan Trinh et al. · Antimicrobial Agents and Chemotherapy · 2012 · 51 citations · Full text

, , +17

An easy procedure for in vivo estimation of protein binding and correction of elevated serum values induced by venous stasis

Claus Christiansen, J Naestoft, Eigill F. Hvidberg et al. · Clinica Chimica Acta · 1975 · 50 citations

, , +7

1–5 of 10

Authors

59

  1. JF
    Jianwei Fan

    Manhattan University, United States

    1 publications · 39 citations

    1

    h-index

  2. SS
    Shao‐Cong Sun

    The University of Texas MD Anderson Cancer Center, United States

    1 publications · 22 citations

    1

    h-index

  3. MS
    Magang Shou

    United States Military Academy, United States

    1 publications · 87 citations

    1

    h-index

  4. JR
    J.T. Regan

    Ollscoil na Gaillimhe – University of Galway, Ireland

    1 publications · 39 citations

    1

    h-index

  5. XQ
    Xiaole Qi

    Harbin Veterinary Research Institute, China

    1 publications · 22 citations

    1

    h-index

1–5 of 59

Institutions

21

  1. Emory University

    Atlanta, United States

    1 h-index

    1 publications

    51 citations

  2. Research Triangle Park Foundation

    Durham, United States

    1 h-index

    3 publications

    171 citations

  3. Rigshospitalet

    Copenhagen, Denmark

    1 h-index

    1 publications

    50 citations

  4. Czech Academy of Sciences, Institute of Physiology

    Prague, Czechia

    1 h-index

    1 publications

    498 citations

  5. Medical Center Hospital

    Odessa, United States

    1 h-index

    3 publications

    81 citations

  6. Daiichi-Sankyo (Japan)

    Tokyo, Japan

    1 h-index

    2 publications

    56 citations

  7. Glostrup Hospital

    Glostrup Municipality, Denmark

    1 h-index

    4 publications

    200 citations

  8. Achillion Pharmaceuticals (United States)

    New Haven, United States

    1 h-index

    2 publications

    44 citations

1–8 of 21

Venues

  1. Antimicrobial Agents and Chemotherapy

    AAC · 3 publications · 135 citations

    3

    h-index

  2. Clinica Chimica Acta

    CCA · 1 publications · 50 citations

    1

    h-index

  3. Molecular Pharmaceutics

    1 publications · 87 citations

    1

    h-index

  4. ACS Pharmacology & Translational Science

    1 publications · 39 citations

    1

    h-index

  5. Theoretical Biology and Medical Modelling

    1 publications · 38 citations

    1

    h-index

1–5