Mark S. Dennis

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

Jagath R. Junutula, Helga Raab, Suzanna Clark et al. · Nature Biotechnology · 2008 · 1.4K citations

Pharmacy, Pharmaceutics, Pharmacology +16

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

Yichao Yu, Yin Zhang, Margaret Kenrick et al. · Science Translational Medicine · 2011 · 800 citations

Pharmacy, Molecular Pharmaceutics, Pharmaceutics +17

Albumin Binding as a General Strategy for Improving the Pharmacokinetics of Proteins

Mark S. Dennis, Min Zhang, Miryam Kadkhodayan et al. · Journal of Biological Chemistry · 2002 · 498 citations · Full text

Life Sciences, Pharmaceutics, Pharmacokinetics +13

Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates

Yang Yu, Jasvinder K. Atwal, Yin Zhang et al. · Science Translational Medicine · 2014 · 369 citations

Pharmacy, Neuroscience, Pharmacology +17

Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys

Mihalis S. Kariolis, Robert C. Wells, Jennifer A. Getz et al. · Science Translational Medicine · 2020 · 355 citations

Pharmacy, Pharmaceutics, Pharmacology +17