Mark S. Dennis

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

Jagath R. Junutula, Helga Raab, Suzanna Clark et al. · Nature Biotechnology · 2008 · 1.3K citations

Medicinal Chemistry, Immunocytochemical Technique, Drug Targeting +10

Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target

Yichao Yu, Yin Zhang, Margaret Kenrick et al. · Science Translational Medicine · 2011 · 780 citations

Albumin Binding as a General Strategy for Improving the Pharmacokinetics of Proteins

Mark S. Dennis, Min Zhang, Miryam Kadkhodayan et al. · Journal of Biological Chemistry · 2002 · 494 citations · Full text

Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates

Yang Yu, Jasvinder K. Atwal, Yin Zhang et al. · Science Translational Medicine · 2014 · 355 citations

Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants

Nga Bien‐Ly, Yang Yu, Daniela Bumbaca et al. · The Journal of Experimental Medicine · 2014 · 336 citations · Full text

Immunology, Brain Exposure, Therapeutics +16