Concepedia

Protease Evolution

Protease Evolution is a computational framework that models the phylogenetic and functional diversification of proteolytic enzymes across biological lineages to infer evolutionary mechanisms driving substrate specificity and catalytic activity.

303

Publications

21.9K

Citations

1.2K

Authors

422

Institutions

Publications per year

2017–2026

33

Parents

Publications

303

Evolutionary families of peptidases

Neil D. Rawlings, A. John Barrett · Biochemical Journal · 1993 · 920 citations · Full text

, , +15

[13] Evolutionary families of metallopeptidases

Neil D. Rawlings, A. John Barrett · Methods in enzymology on CD-ROM/Methods in enzymology · 1995 · 811 citations

, , +4

Structural evidence for gene duplication in the evolution of the acid proteases

Jordan Tang, Michael N.G. James, I.-N. Hsu et al. · Nature · 1978 · 408 citations

, , +16

Alignment/Phylogeny of the Papain Superfamily of Cysteine Proteases

Paul J. Berti, Andrew C. Storer · Journal of Molecular Biology · 1995 · 392 citations

, , +14

Discovery of potential multi-target-directed ligands by targeting host-specific SARS-CoV-2 structurally conserved main protease

Rakesh S. Joshi, Shounak Jagdale, Sneha B. Bansode et al. · Journal of Biomolecular Structure and Dynamics · 2020 · 362 citations · Full text

, , +16

1–5 of 303

Authors

1.2K

  1. ED
    Enrico Di

    Washington University in St. Louis, United States

    5 publications · 280 citations

    5

    h-index

  2. MM
    Maxwell M. Krem

    Medical College of Wisconsin, United States

    4 publications · 337 citations

    4

    h-index

  3. JH
    James H. McKerrow

    University of California, San Francisco, United States

    4 publications · 405 citations

    4

    h-index

  4. GP
    Gerhard Pfleiderer

    University of Stuttgart, Germany

    3 publications · 84 citations

    3

    h-index

  5. RZ
    Robert Zwilling

    Heidelberg University, Germany

    3 publications · 171 citations

    3

    h-index

1–5 of 1.2K

Institutions

422

  1. Washington University in St. Louis

    St Louis, United States

    10 h-index

    19 publications

    1.3K citations

  2. University of California, San Francisco

    San Francisco, United States

    8 h-index

    36 publications

    3.9K citations

  3. Max Planck Institute of Biochemistry

    Martinsried, Germany

    7 h-index

    32 publications

    2.7K citations

  4. Cornell University

    Ithaca, United States

    6 h-index

    14 publications

    710 citations

  5. Max Planck Society

    Munich, Germany

    6 h-index

    28 publications

    3.6K citations

  6. Howard Hughes Medical Institute

    Chevy Chase, United States

    5 h-index

    11 publications

    703 citations

  7. University of Cambridge

    Cambridge, United Kingdom

    5 h-index

    13 publications

    565 citations

  8. Harvard University

    Cambridge, United States

    5 h-index

    17 publications

    1.4K citations

1–8 of 422

Venues

  1. Journal of Biological Chemistry

    JBC · 16 publications · 1.1K citations

    16

    h-index

  2. Molecular Biology and Evolution

    MBE · 16 publications · 803 citations

    15

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 12 publications · 1.4K citations

    12

    h-index

  4. FEBS Letters

    9 publications · 853 citations

    9

    h-index

  5. BMC Evolutionary Biology

    8 publications · 659 citations

    8

    h-index

1–5