Concepedia

Promoter Pausing

Promoter Pausing is a regulatory mechanism in transcriptional control wherein RNA polymerase II initiates transcription but halts elongation within a short distance downstream of the promoter, thereby maintaining the polymerase in a transcriptionally engaged yet paused state until specific signals trigger its release into productive elongation.

149

Publications

14K

Citations

776

Authors

260

Institutions

Publications per year

2017–2026

67

Variants

Promoter-proximal Pausing

Parents

Publications

149

Precise Maps of RNA Polymerase Reveal How Promoters Direct Initiation and Pausing

Hojoong Kwak, Nicholas J. Fuda, Leighton J. Core et al. · Science · 2013 · 934 citations

, , +17

The Transcriptional and Epigenomic Foundations of Ground State Pluripotency

Hendrik Marks, Tüzer Kalkan, Roberta Menafra et al. · Cell · 2012 · 861 citations · Full text

, , +17

Genome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing, chromatin, and exons

Iris H. Jonkers, Hojoong Kwak, John T. Lis · eLife · 2014 · 631 citations · Full text

, , +17

Transcription Regulation Through Promoter-Proximal Pausing of RNA Polymerase II

Leighton J. Core, John T. Lis · Science · 2008 · 400 citations · Full text

, , +17

R-ChIP Using Inactive RNase H Reveals Dynamic Coupling of R-loops with Transcriptional Pausing at Gene Promoters

Liang Chen, Jiayu Chen, Xuan Zhang et al. · Molecular Cell · 2017 · 390 citations · Full text

, , +12

1–5 of 149

Authors

776

  1. JT
    John T. Lis

    Cornell University, United States

    11 publications · 2.9K citations

    11

    h-index

  2. DS
    David S. Gilmour

    Pennsylvania State University, United States

    8 publications · 935 citations

    8

    h-index

  3. AS
    Ali Shilatifard

    Northwestern University, United States

    5 publications · 765 citations

    5

    h-index

  4. LJ
    Leighton J. Core

    Cornell University, United States

    5 publications · 1.7K citations

    5

    h-index

  5. DS
    Donal S. Luse

    University of Cincinnati Medical Center, United States

    5 publications · 214 citations

    5

    h-index

1–5 of 776

Institutions

260

  1. Cornell University

    Ithaca, United States

    17 h-index

    65 publications

    11.5K citations

  2. Pennsylvania State University

    State College, United States

    11 h-index

    49 publications

    6.2K citations

  3. Harvard University

    Cambridge, United States

    11 h-index

    67 publications

    6.2K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    10 h-index

    30 publications

    3.6K citations

  5. University of California, Berkeley

    Berkeley, United States

    8 h-index

    19 publications

    2.5K citations

  6. Northwestern University

    Evanston, United States

    7 h-index

    39 publications

    5.2K citations

  7. National Institutes of Health

    Bethesda, United States

    7 h-index

    24 publications

    1.5K citations

  8. Stowers Institute for Medical Research

    Kansas City, United States

    6 h-index

    25 publications

    1.7K citations

1–8 of 260

Venues

  1. Nucleic Acids Research

    18 publications · 1.1K citations

    16

    h-index

  2. Molecular Cell

    16 publications · 1.6K citations

    16

    h-index

  3. Genes & Development

    10 publications · 1.8K citations

    10

    h-index

  4. Nature Communications

    10 publications · 678 citations

    10

    h-index

  5. Journal of Biological Chemistry

    JBC · 8 publications · 369 citations

    8

    h-index

1–5