R-ChIP Using Inactive RNase H Reveals Dynamic Coupling of R-loops with Transcriptional Pausing at Gene Promoters

Liang Chen, Jiayu Chen, Xuan Zhang, +10

Molecular Cell

Transcriptional RegulationNatural SciencesGeneticsGene PromotersMolecular Biology +8

METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation

Canfeng Zhang, Liping Chen, Di Peng, +11

Molecular Cell

Genome InstabilityDna-rna Hybrid AccumulationNatural SciencesGeneticsGenomic Mechanism +4

The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations

Liang Chen, Jiayu Chen, Yi-Jou Huang, +12

Molecular Cell

Hematological MalignancyChromatinAugmented R-loopMyelodysplastic Syndromes InducedGenetics +8

Single-cell Stereo-seq reveals induced progenitor cells involved in axolotl brain regeneration

Xiaoyu Wei, Sulei Fu, Hanbo Li, +33

Science

AMPK-mediated activation of MCU stimulates mitochondrial Ca2+ entry to promote mitotic progression

Haixin Zhao, Teng Li, Kai Wang, +14

Nature Cell Biology

MitophagySignal TransductionCell DivisionMitochondrial FunctionAmpk-mediated Activation +9

Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex

Lanfeng Wang, Yu Zhou, Liang Xu, +8

Nature

EngineeringMolecular Biological MethodNatural SciencesRna Structure PredictionRna Biology +6

GC content around splice sites affects splicing through pre-mRNA secondary structures

Jing Zhang, C.‐C. Jay Kuo, Liang Chen

BMC Genomics

Genomic profiling of native R loops with a DNA-RNA hybrid recognition sensor

Wang Kang, Honghong Wang, Conghui Li, +9

Science Advances

RBFox2 Binds Nascent RNA to Globally Regulate Polycomb Complex 2 Targeting in Mammalian Genomes

Chaoliang Wei, Rui Xiao, Liang Chen, +10

Molecular Cell

ChromatinTranscriptional RegulationNatural SciencesMammalian GenomesRna Biology +8

SRSF2 Is Essential for Hematopoiesis, and Its Myelodysplastic Syndrome-Related Mutations Dysregulate Alternative Pre-mRNA Splicing

Yukiko Komeno, Yi-Jou Huang, Jinsong Qiu, +10

Molecular and Cellular Biology

Hematological MalignancyDevelopmental BiologyMixed-phenotype Acute LeukemiaGeneticsIntact Srsf2 +11