Concepedia

Profile-sequence Alignment

Profile-Sequence Alignment is a computational method in bioinformatics that aligns a biological sequence to a profile—typically derived from a multiple sequence alignment—by optimizing the fit of the sequence to the position-specific scoring model encoded in the profile, distinguishing it from pairwise or sequence-to-sequence alignment methods through its use of evolutionary and statistical information aggregated across homologous sequences.

70

Publications

48.7K

Citations

195

Authors

105

Institutions

Publications per year

2017–2026

8

Variants

Profile-to-sequence Alignment

Parents

Publications

70

The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools

Julie Thompson · Nucleic Acids Research · 1997 · 39.2K citations · Full text

, , +13

Multiple Sequence Alignment Using ClustalW and ClustalX

Julie Thompson, Toby J. Gibson, Desmond G. Higgins · Current Protocols in Bioinformatics · 2002 · 3.1K citations

, , +14

Protein–ligand binding site recognition using complementary binding-specific substructure comparison and sequence profile alignment

Jianyi Yang, Ambrish Roy, Yang Zhang · Bioinformatics · 2013 · 1.1K citations · Full text

, , +13

FFAS03: a server for profile-profile sequence alignments

Lukasz Jaroszewski, Leszek Rychlewski, Z. Li et al. · Nucleic Acids Research · 2005 · 605 citations · Full text

, , +16

Detecting evolutionary relationships across existing fold space, using sequence order-independent profile–profile alignments

Lei Xie, Philip E. Bourne · Proceedings of the National Academy of Sciences · 2008 · 251 citations · Full text

, , +15

1–5 of 70

Authors

195

  1. AG
    Adam Godzik

    Sanford Burnham Prebys Medical Discovery Institute, United States

    5 publications · 1.1K citations

    5

    h-index

  2. LJ
    Lukasz Jaroszewski

    University of California San Diego, United States

    4 publications · 1.1K citations

    4

    h-index

  3. JT
    Julie Thompson

    Centre National de la Recherche Scientifique, France

    3 publications · 42.4K citations

    3

    h-index

  4. RI
    Ruslan I. Sadreyev

    Massachusetts General Hospital, United States

    3 publications · 284 citations

    3

    h-index

  5. AV
    Alfonso Valencia

    Spanish National Cancer Research Centre, Spain

    3 publications · 123 citations

    3

    h-index

1–5 of 195

Institutions

105

  1. European Molecular Biology Laboratory

    Heidelberg, Germany

    4 h-index

    4 publications

    3.5K citations

  2. Sanford Burnham Prebys Medical Discovery Institute

    La Jolla, United States

    4 h-index

    12 publications

    1.8K citations

  3. National Center for Biotechnology Information

    Bethesda, United States

    4 h-index

    10 publications

    830 citations

  4. National Institutes of Health

    Bethesda, United States

    4 h-index

    10 publications

    830 citations

  5. Howard Hughes Medical Institute

    Chevy Chase, United States

    4 h-index

    10 publications

    752 citations

  6. San Diego Supercomputer Center

    San Diego, United States

    3 h-index

    6 publications

    792 citations

  7. The University of Texas Southwestern Medical Center

    Dallas, United States

    3 h-index

    7 publications

    751 citations

  8. European Molecular Biology Laboratory

    Hamburg, Germany

    3 h-index

    5 publications

    591 citations

1–8 of 105

Venues

  1. Bioinformatics

    18 publications · 2.3K citations

    15

    h-index

  2. Nucleic Acids Research

    12 publications · 40.7K citations

    11

    h-index

  3. BMC Bioinformatics

    6 publications · 156 citations

    6

    h-index

  4. Protein Science

    PS · 3 publications · 449 citations

    3

    h-index

  5. 2

    h-index

1–5