Concepedia

Prodomain-mediated Activation

Prodomain-Mediated Activation is a molecular mechanism in the caspase activation pathway in which the prodomain functions as a regulatory module that facilitates the recruitment and proximity-induced autoactivation of caspase zymogens through homotypic interactions in multiprotein signaling complexes.

29

Publications

1.9K

Citations

147

Authors

58

Institutions

Publications per year

2017–2026

2

Parents

Publications

29

Type II Metacaspases Atmc4 and Atmc9 of Arabidopsis thaliana Cleave Substrates after Arginine and Lysine

Dominique Vercammen, Brigitte van de Cotte, Geert De Jaeger et al. · Journal of Biological Chemistry · 2004 · 352 citations · Full text

, , +17

The Prodomain of BMP-7 Targets the BMP-7 Complex to the Extracellular Matrix

Kate E. Gregory, Robert N. Ono, Noé L. Charbonneau et al. · Journal of Biological Chemistry · 2005 · 203 citations · Full text

, , +14

The prodomain of caspase-3 regulates its own removal and caspase activation

Katelyn G. Ponder, Lawrence Boise · Cell Death Discovery · 2019 · 138 citations · Full text

, , +15

X-ray Structure of Human proMMP-1

Daniela Jozic, Gleb Bourenkov, Ngee Han Lim et al. · Journal of Biological Chemistry · 2004 · 120 citations · Full text

, , +14

Dimerization and Autoprocessing of the Nedd2 (Caspase-2) Precursor Requires both the Prodomain and the Carboxyl-terminal Regions

Alison J. Butt, Natasha L. Harvey, Gayathri Parasivam et al. · Journal of Biological Chemistry · 1998 · 112 citations · Full text

, , +13

1–5 of 29

Authors

147

  1. SK
    Sharad Kumar

    South Australia Pathology, Australia

    3 publications · 296 citations

    3

    h-index

  2. AY
    Alex Y. Strongin

    Sanford Burnham Prebys Medical Discovery Institute, United States

    3 publications · 83 citations

    3

    h-index

  3. KM
    Khatereh Motamedchaboki

    Sanford Burnham Prebys Medical Discovery Institute, United States

    2 publications · 66 citations

    2

    h-index

  4. KG
    Katarzyna Gawlik

    Jagiellonian University, Poland

    2 publications · 66 citations

    2

    h-index

  5. AW
    Albrecht WENDEL

    University of Konstanz, Germany

    2 publications · 73 citations

    2

    h-index

1–5 of 147

Institutions

58

  1. Sanford Burnham Prebys Medical Discovery Institute

    La Jolla, United States

    3 h-index

    20 publications

    618 citations

  2. Hanson Institute

    Adelaide, Australia

    3 h-index

    10 publications

    1K citations

  3. South Australia Pathology

    Adelaide, Australia

    2 h-index

    5 publications

    524 citations

  4. Institute for Medical Research

    Durham, United States

    2 h-index

    17 publications

    567 citations

  5. Oregon Health & Science University

    Portland, United States

    2 h-index

    7 publications

    745 citations

  6. Université de Sherbrooke

    Sherbrooke, Canada

    2 h-index

    4 publications

    146 citations

  7. University of Konstanz

    Konstanz, Germany

    2 h-index

    9 publications

    337 citations

  8. QB3

    San Francisco, United States

    1 h-index

    2 publications

    118 citations

1–8 of 58

Venues

  1. Journal of Biological Chemistry

    JBC · 9 publications · 1K citations

    9

    h-index

  2. PLoS ONE

    3 publications · 110 citations

    3

    h-index

  3. Cell Death and Differentiation

    CDD · 2 publications · 154 citations

    2

    h-index

  4. Biochemical Journal

    BJ · 2 publications · 73 citations

    2

    h-index

  5. Molecular Biology of the Cell

    MBC · 1 publications · 15 citations

    1

    h-index

1–5