Concepedia

Privileged Structure-based Design

Privileged Structure-Based Design is a molecular design strategy in diversity-oriented synthesis that leverages biologically relevant, scaffold-rich frameworks—termed privileged structures—to guide the efficient generation of structurally diverse and functionally potent compound libraries.

77

Publications

4.7K

Citations

440

Authors

159

Institutions

Publications per year

2017–2026

21

Parents

Publications

77

Natural Product-like Combinatorial Libraries Based on Privileged Structures. 1. General Principles and Solid-Phase Synthesis of Benzopyrans

K. C. Nicolaou, Jeffrey A. Pfefferkorn, Anthony J. Roecker et al. · Journal of the American Chemical Society · 2000 · 674 citations

, , +13

Privileged Structures as Leads in Medicinal Chemistry

Luca Costantino, Daniela Barlocco · Current Medicinal Chemistry · 2005 · 329 citations

, , +12

8-Hydroxyquinoline: a privileged structure with a broad-ranging pharmacological potential

Yuning Song, Hao Xu, Wen‐Ming Chen et al. · MedChemComm · 2014 · 232 citations

, , +10

Natural Product-like Combinatorial Libraries Based on Privileged Structures. 3. The “Libraries from Libraries” Principle for Diversity Enhancement of Benzopyran Libraries

K. C. Nicolaou, Jeffrey A. Pfefferkorn, Sofía Barluenga et al. · Journal of the American Chemical Society · 2000 · 193 citations

, , +17

Quinoxalin-2(1<i>H</i>)-One Derivatives As Inhibitors Against Hepatitis C Virus

Rui Liu, Zhuhui Huang, Michael G. Murray et al. · Journal of Medicinal Chemistry · 2011 · 158 citations

, , +16

1–5 of 77

Authors

440

  1. SB
    Seung Bum Park

    Seoul National University, South Korea

    4 publications · 272 citations

    4

    h-index

  2. PL
    Paul L. Ornstein

    Eli Lilly (United States), United States

    3 publications · 38 citations

    3

    h-index

  3. JM
    John M. Zgombick

    Eli Lilly (United States), United States

    3 publications · 38 citations

    3

    h-index

  4. MJ
    Matthew J. Fisher

    Eli Lilly (United States), United States

    3 publications · 38 citations

    3

    h-index

  5. KB
    Karin Briner

    Eli Lilly (United States), United States

    3 publications · 38 citations

    3

    h-index

1–5 of 440

Institutions

159

  1. Seoul National University

    Seoul, South Korea

    4 h-index

    14 publications

    803 citations

  2. Eli Lilly (United States)

    Indianapolis, United States

    3 h-index

    30 publications

    374 citations

  3. Pfizer (United States)

    New York, United States

    2 h-index

    12 publications

    1.7K citations

  4. Universidad Autónoma de Madrid

    Madrid, Spain

    2 h-index

    3 publications

    77 citations

  5. Chinese Academy of Sciences

    Beijing, China

    2 h-index

    14 publications

    355 citations

  6. Shanghai Institute of Materia Medica

    Pudong, China

    2 h-index

    14 publications

    355 citations

  7. Universidade Federal de Alagoas

    Maceió, Brazil

    2 h-index

    4 publications

    132 citations

  8. Shandong University

    Jinan, China

    2 h-index

    15 publications

    1.3K citations

1–8 of 159

Venues

  1. Journal of Medicinal Chemistry

    8 publications · 603 citations

    8

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    6 publications · 192 citations

    6

    h-index

  3. ACS Combinatorial Science

    5 publications · 138 citations

    5

    h-index

  4. Journal of the American Chemical Society

    JACS · 4 publications · 1.1K citations

    4

    h-index

  5. Chemical Communications

    ChemComm · 3 publications · 226 citations

    3

    h-index

1–5