Prime Editing Efficiency Optimization is a computational or experimental methodology designed to enhance the precision, yield, and reproducibility of prime editing outcomes by systematically refining editing parameters, guide design, delivery strategies, or cellular conditions to maximize target modification accuracy and minimize off-target effects.
27
Publications
3.7K
Citations
236
Authors
83
Institutions
Publications per year
2017–2026
27
Parents
Publications
27
Enhanced prime editing systems by manipulating cellular determinants of editing outcomes
Peter J. Chen, Jeffrey A. Hussmann, Jun Yan et al. · Cell · 2021 · 799 citations · Full text
Engineered pegRNAs improve prime editing efficiency
James W. Nelson, Peyton B. Randolph, Simon P. Shen et al. · Nature Biotechnology · 2021 · 717 citations · Full text
Prime editing efficiently generates W542L and S621I double mutations in two ALS genes in maize
Yuanyuan Jiang, Yiping Chai, Minhui Lu et al. · Genome biology · 2020 · 274 citations · Full text
Efficient generation of mouse models with the prime editing system
Yao Liu, Xiangyang Li, Siting He et al. · Cell Discovery · 2020 · 241 citations · Full text
An engineered prime editor with enhanced editing efficiency in plants
Yuan Zong, Yijing Liu, Chenxiao Xue et al. · Nature Biotechnology · 2022 · 240 citations
1–5 of 27
Authors
236
- XH
4
h-index
- ML
3
h-index
- YJ
3
h-index
- GA
3
h-index
- PLPengpeng Liu
University of Massachusetts Chan Medical School, United States
3 publications · 81 citations
3
h-index
1–5 of 236
Institutions
83
Chinese Academy of Sciences
Beijing, China
6 h-index
26 publications
3K citations
University of Chinese Academy of Sciences
Beijing, China
6 h-index
22 publications
2.6K citations
ShanghaiTech University
Shanghai, China
5 h-index
19 publications
1.8K citations
Broad Institute
Cambridge, United States
4 h-index
24 publications
12.3K citations
Harvard University
Cambridge, United States
4 h-index
30 publications
12.7K citations
Harvard University Press
Cambridge, United States
3 h-index
3 publications
1.6K citations
Howard Hughes Medical Institute
Chevy Chase, United States
3 h-index
25 publications
13.1K citations
China Agricultural University
Beijing, China
3 h-index
24 publications
2.9K citations
1–8 of 83
Venues
- Nature Biotechnology
5 publications · 1.2K citations
5
h-index
- Genome biology
3 publications · 500 citations
3
h-index
- Nature Communications
3 publications · 174 citations
3
h-index
- bioRxiv (Cold Spring Harbor Laboratory)
Repository · 2 publications · 57 citations
2
h-index
- Cell
2 publications · 914 citations
2
h-index
1–5