Concepedia

Presystemic Elimination

Presystemic Elimination is a pharmacokinetic phenomenon characterized by the metabolic degradation of an administered drug during its initial passage through the liver prior to entering the systemic circulation, thereby reducing its bioavailability.

41

Publications

1.7K

Citations

172

Authors

50

Institutions

Publications per year

2017–2026

1

Parents

Publications

41

Systemic delivery of peptides and proteins across absorptive mucosae.

Amyn Sayani, Yie W. Chien · PubMed · 1996 · 161 citations

, , +17

A role for constitutive androstane receptor in the regulation of human intestinal MDR1 expression

Oliver Burk, Katja A. Arnold, Anke Geick et al. · Biological Chemistry · 2005 · 154 citations

, , +16

The effects of diet, aging and disease-states on presystemic elimination and oral drug bioavailability in humans

G. Wilkinson · Advanced Drug Delivery Reviews · 1997 · 142 citations

, , +14

Felodipine kinetics in healthy men

Boo Edgar, C G Regårdh, G. Johnsson et al. · Clinical Pharmacology & Therapeutics · 1985 · 111 citations

, , +16

Pulmonary Drug Delivery: Physiologic and Mechanistic Aspects

Jianwei Yu, Yie W. Chien · Critical Reviews in Therapeutic Drug Carrier Systems · 1997 · 94 citations

, , +17

1–5 of 41

Authors

172

  1. CG
    C G Regårdh

    AstraZeneca (Sweden), Sweden

    2 publications · 158 citations

    2

    h-index

  2. OR
    Ola Rönn

    Sahlgrenska University Hospital, Sweden

    2 publications · 158 citations

    2

    h-index

  3. BE
    Boo Edgar

    University of Gothenburg, Sweden

    2 publications · 158 citations

    2

    h-index

  4. YW
    Yie W. Chien

    Rutgers, The State University of New Jersey, United States

    2 publications · 255 citations

    2

    h-index

  5. PL
    Per Lundborg

    University of Gothenburg, Sweden

    2 publications · 158 citations

    2

    h-index

1–5 of 172

Institutions

50

  1. National Cancer Institute

    Bethesda, United States

    2 h-index

    2 publications

    36 citations

  2. Rutgers, The State University of New Jersey

    New Brunswick, United States

    2 h-index

    3 publications

    349 citations

  3. Universidad de Montevideo

    Montevideo, Uruguay

    1 h-index

    3 publications

    48 citations

  4. University of Georgia

    Athens, United States

    1 h-index

    3 publications

    72 citations

  5. Johannes Gutenberg University Mainz

    Mainz, Germany

    1 h-index

    7 publications

    420 citations

  6. National Institute for Public Health and the Environment

    De Bilt, The Netherlands

    1 h-index

    3 publications

    132 citations

  7. Tokyo University of Pharmacy and Life Sciences

    Hachiōji, Japan

    1 h-index

    1 publications

    36 citations

  8. University Hospital Bonn

    Bonn, Germany

    1 h-index

    1 publications

    17 citations

1–8 of 50

Venues

  1. PubMed

    Repository · 6 publications · 342 citations

    6

    h-index

  2. 4

    h-index

  3. Clinical Pharmacology & Therapeutics

    CPT · 3 publications · 196 citations

    3

    h-index

  4. British Journal of Clinical Pharmacology

    BJCP · 3 publications · 57 citations

    3

    h-index

  5. Biopharmaceutics & Drug Disposition

    3 publications · 143 citations

    3

    h-index

1–5