Concepedia

Preiss-handler Pathway

The Preiss-Handler Pathway is a biochemical metabolic pathway that synthesizes nicotinamide adenine dinucleotide (NAD+) from nicotinic acid through a series of enzymatic reactions involving phosphoribosylation, adenylylation, and dephosphorylation, distinguishing it from alternative NAD+ biosynthetic routes by its specific substrate origin and intermediate steps.

20

Publications

1.6K

Citations

129

Authors

63

Institutions

Publications per year

2017–2026

6

Parents

Publications

20

Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans

Paweł Bieganowski, Charles Brenner · Cell · 2004 · 759 citations · Full text

, , +14

Nicotinamide Riboside Kinase Structures Reveal New Pathways to NAD+

W. Tempel, Wael M. Rabeh, Katrina L. Bogan et al. · PLoS Biology · 2007 · 159 citations · Full text

, , +13

BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities

Keisuke Yaku, Sailesh Palikhe, Hironori Izumi et al. · Nature Communications · 2021 · 77 citations · Full text

, , +13

Formation of the Nicotinic Acid Analogue of Diphosphopyridine Nucleotide after Nicotinamide Administration

Thomas A. Langan, Nathan O. Kaplan, Louis Shuster · Journal of Biological Chemistry · 1959 · 73 citations · Full text

, , +12

Pathway analysis of NAD+ metabolism

Luís F. de Figueiredo, Toni I. Gossmann, Mathias Ziegler et al. · Biochemical Journal · 2011 · 65 citations · Full text

, , +15

1–5 of 20

Authors

129

  1. MZ
    Mathias Ziegler

    University of Bergen, Norway

    2 publications · 117 citations

    2

    h-index

  2. LF
    Luís F. de Figueiredo

    Friedrich Schiller University Jena, Germany

    2 publications · 117 citations

    2

    h-index

  3. JF
    Jorge Franco

    Innova (Italy), Italy

    2 publications · 32 citations

    2

    h-index

  4. MG
    Moustafa Ghanem

    Ospedale Policlinico San Martino, Italy

    2 publications · 32 citations

    2

    h-index

  5. TI
    Toni I. Gossmann

    University of Sheffield, United Kingdom

    2 publications · 117 citations

    2

    h-index

1–5 of 129

Institutions

63

  1. National Research Council

    Rome, Italy

    2 h-index

    3 publications

    52 citations

  2. University of Bergen

    Bergen, Norway

    2 h-index

    4 publications

    234 citations

  3. University of Genoa

    Genoa, Italy

    2 h-index

    16 publications

    264 citations

  4. University of Sussex

    Brighton, United Kingdom

    2 h-index

    2 publications

    117 citations

  5. Universidad de Sevilla

    Seville, Spain

    2 h-index

    9 publications

    132 citations

  6. Dartmouth College

    Hanover, United States

    2 h-index

    7 publications

    2.3K citations

  7. Ospedale Policlinico San Martino

    Genoa, Italy

    2 h-index

    3 publications

    52 citations

  8. Friedrich Schiller University Jena

    Jena, Germany

    2 h-index

    5 publications

    286 citations

1–8 of 63

Venues

  1. Pharmaceuticals

    2 publications · 32 citations

    2

    h-index

  2. Cell

    1 publications · 759 citations

    1

    h-index

  3. Theranostics

    1 publications · 16 citations

    1

    h-index

  4. Journal of Bacteriology

    JB · 1 publications · 33 citations

    1

    h-index

  5. PLANT PHYSIOLOGY

    1 publications · 33 citations

    1

    h-index

1–5