Concepedia

Predictive Preclinical Modeling

Predictive Preclinical Modeling is a formal scientific framework that systematically integrates reverse translation principles to extrapolate clinical outcomes from preclinical data, distinguished by its emphasis on bidirectional validation between therapeutic efficacy in human trials and underlying biological mechanisms observed in animal or in vitro models.

43

Publications

2.8K

Citations

343

Authors

168

Institutions

Publications per year

2017–2026

24

Parents

Publications

43

Animal models in translational medicine: Validation and prediction

Tinneke Denayer, Thomas Stöhr, Maarten Van Roy · European Journal of Molecular & Clinical Medicine · 2014 · 446 citations

, , +16

Human Tumor Xenografts as Predictive Preclinical Models for Anticancer Drug Activity in Humans: Better than Commonly Perceived—But They Can Be Improved

Robert S. Kerbel · Cancer Biology & Therapy · 2003 · 325 citations · Full text

, , +14

Reproducibility of preclinical animal research improves with heterogeneity of study samples

Bernhard Voelkl, Lucile Vogt, Emily S. Sena et al. · PLoS Biology · 2018 · 264 citations · Full text

, , +15

Animal models of wound repair: Are they cutting it?

David M. Ansell, Kirsty Holden, Matthew J. Hardman · Experimental Dermatology · 2012 · 138 citations · Full text

, , +13

Stemness and chemoresistance in epithelial ovarian carcinoma cells under shear stress

Carman Ka Man Ip, Shanshan Li, Matthew Y. H. Tang et al. · Scientific Reports · 2016 · 133 citations · Full text

, , +17

1–5 of 43

Authors

343

  1. WN
    William Nguyen

    Stanford University, United States

    2 publications · 103 citations

    2

    h-index

  2. AG
    Andre Ghetti

    AnaBios (United States), United States

    2 publications · 103 citations

    2

    h-index

  3. NA
    Najah Abi‐Gerges

    AstraZeneca (United Kingdom), United Kingdom

    2 publications · 103 citations

    2

    h-index

  4. PE
    Paul E. Miller

    AnaBios (United States), United States

    2 publications · 103 citations

    2

    h-index

  5. NN
    Nathalie Nguyen

    San Diego State University, United States

    2 publications · 103 citations

    2

    h-index

1–5 of 343

Institutions

168

  1. National Institutes of Health

    Bethesda, United States

    3 h-index

    7 publications

    249 citations

  2. Pfizer (United States)

    New York, United States

    3 h-index

    10 publications

    484 citations

  3. Great Ormond Street Hospital

    London, United Kingdom

    2 h-index

    8 publications

    178 citations

  4. The University of Melbourne

    Melbourne, Australia

    2 h-index

    7 publications

    153 citations

  5. Dana-Farber Cancer Institute

    Boston, United States

    2 h-index

    12 publications

    273 citations

  6. Jackson Laboratory

    Bar Harbor, United States

    2 h-index

    5 publications

    146 citations

  7. Sydney Children’s Hospitals Network

    Sydney, Australia

    2 h-index

    7 publications

    155 citations

  8. University College London

    London, United Kingdom

    2 h-index

    8 publications

    178 citations

1–8 of 168

Venues

  1. Scientific Reports

    3 publications · 181 citations

    3

    h-index

  2. PubMed

    Repository · 3 publications · 170 citations

    3

    h-index

  3. Cancers

    3 publications · 111 citations

    3

    h-index

  4. Frontiers in Pharmacology

    2 publications · 27 citations

    2

    h-index

  5. Clinical Pharmacokinetics

    1 publications · 10 citations

    1

    h-index

1–5