Concepedia

Precursor-directed Combinatorial Biosynthesis

Precursor-Directed Combinatorial Biosynthesis is a methodological approach in synthetic biology wherein structurally related exogenous precursors are selectively incorporated into biosynthetic pathways to generate diverse natural product analogs, differing from conventional combinatorial biosynthesis by its reliance on substrate promiscuity rather than genetic manipulation of biosynthetic enzymes.

29

Publications

1.5K

Citations

160

Authors

51

Institutions

Publications per year

2017–2026

7

Parents

Publications

29

New Lessons for Combinatorial Biosynthesis from Myxobacteria

Barbara Silakowski, Hans Ulrich Schairer, Heidi Ehret et al. · Journal of Biological Chemistry · 1999 · 254 citations · Full text

, , +12

Combinatorial biosynthesis of antitumor indolocarbazole compounds

César Sánchez, Alfredo F. Braña, Aaroa P. Salas et al. · Proceedings of the National Academy of Sciences · 2004 · 246 citations · Full text

, , +17

Releasing the potential power of terpene synthases by a robust precursor supply platform

Guangkai Bian, Yichao Han, Anwei Hou et al. · Metabolic Engineering · 2017 · 123 citations · Full text

, , +17

Precursor-directed biosynthesis of beauvericin analogs by the insect pathogenic fungus Paecilomyces tenuipes BCC 1614

Chongdee Nilanonta, Masahiko Isaka, Prasat Kittakoop et al. · Tetrahedron · 2002 · 94 citations

, , +16

Combinatorial biosynthesis of plant-specific coumarins in bacteria

Yuheng Lin, Xinxiao Sun, Qipeng Yuan et al. · Metabolic Engineering · 2013 · 94 citations

, , +10

1–5 of 29

Authors

160

  1. JR
    Jürgen Rohr

    University of Kentucky, United States

    2 publications · 311 citations

    2

    h-index

  2. CM
    Cármen Méndez

    Universidad de Oviedo, Spain

    2 publications · 311 citations

    2

    h-index

  3. MT
    Morakot Tanticharoen

    National Center for Genetic Engineering and Biotechnology, Thailand

    2 publications · 184 citations

    2

    h-index

  4. CN
    Chongdee Nilanonta

    National Center for Genetic Engineering and Biotechnology, Thailand

    2 publications · 184 citations

    2

    h-index

  5. RJ
    Rebecca J. M. Goss

    University of St Andrews, United Kingdom

    2 publications · 27 citations

    2

    h-index

1–5 of 160

Institutions

51

  1. National Center for Genetic Engineering and Biotechnology

    Pathum Thani, Thailand

    2 h-index

    10 publications

    920 citations

  2. Universidad de Oviedo

    Oviedo, Spain

    2 h-index

    11 publications

    2K citations

  3. University of Kentucky

    Lexington, United States

    2 h-index

    12 publications

    2K citations

  4. Chinese Academy of Sciences

    Beijing, China

    2 h-index

    8 publications

    304 citations

  5. King's College London

    London, United Kingdom

    1 h-index

    2 publications

    34 citations

  6. University of Shizuoka

    Shizuoka, Japan

    1 h-index

    1 publications

    13 citations

  7. University College Dublin

    Dublin, Ireland

    1 h-index

    2 publications

    40 citations

  8. The University of Queensland

    Brisbane, Australia

    1 h-index

    4 publications

    44 citations

1–8 of 51

Venues

  1. Metabolic Engineering

    2 publications · 217 citations

    2

    h-index

  2. Journal of the American Chemical Society

    JACS · 1 publications · 58 citations

    2

    h-index

  3. ACS Synthetic Biology

    2 publications · 36 citations

    2

    h-index

  4. Chemical Communications

    ChemComm · 2 publications · 34 citations

    2

    h-index

  5. Tetrahedron

    2 publications · 184 citations

    2

    h-index

1–5