Concepedia

Precursor Pathway Optimization

Precursor Pathway Optimization is a computational or experimental methodology within metabolic engineering that systematically enhances the biosynthetic flux toward target precursors by redesigning enzymatic pathways, regulatory elements, and substrate utilization to maximize yield, efficiency, and specificity under defined physiological constraints.

21

Publications

1.4K

Citations

111

Authors

43

Institutions

Publications per year

2017–2026

11

Parents

Publications

21

Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene

Jennifer R. Anthony, Larry C. Anthony, Farnaz Nowroozi et al. · Metabolic Engineering · 2008 · 294 citations

, , +16

Optimizing Oleaginous Yeast Cell Factories for Flavonoids and Hydroxylated Flavonoids Biosynthesis

Yongkun Lv, Monireh Marsafari, Mattheos Koffas et al. · ACS Synthetic Biology · 2019 · 203 citations

, , +17

Coupled incremental precursor and co-factor supply improves 3-hydroxypropionic acid production in Saccharomyces cerevisiae

Yun Chen, Jichen Bao, Il‐Kwon Kim et al. · Metabolic Engineering · 2014 · 164 citations

, , +17

The Isogene 1-Deoxy-D-Xylulose 5-Phosphate Synthase 2 Controls Isoprenoid Profiles, Precursor Pathway Allocation, and Density of Tomato Trichomes

Heike Paetzold, Stefan Garms, Stefan Bartram et al. · Molecular Plant · 2010 · 121 citations · Full text

, , +11

Metabolic engineering of Escherichia coli BL21 for biosynthesis of heparosan, a bioengineered heparin precursor

Chunyu Zhang, Long Liu, Liping Teng et al. · Metabolic Engineering · 2012 · 82 citations

, , +16

1–5 of 21

Authors

111

  1. JZ
    Jingwen Zhou

    Jiangnan University, China

    3 publications · 248 citations

    3

    h-index

  2. YL
    Yongkun Lv

    Zhengzhou University, China

    2 publications · 224 citations

    2

    h-index

  3. JD
    Jay D. Keasling

    University of California, Berkeley, United States

    2 publications · 310 citations

    2

    h-index

  4. SX
    Sha Xu

    Jiangnan University, China

    2 publications · 45 citations

    2

    h-index

  5. DM
    Dongxu Ma

    Collaborative Innovation Center of Chemical Science and Engineering Tianjin, China

    1 publications · 14 citations

    1

    h-index

1–5 of 111

Institutions

43

  1. Jiangnan University

    Wuxi, China

    4 h-index

    22 publications

    1.5K citations

  2. Lawrence Berkeley National Laboratory

    Berkeley, United States

    2 h-index

    9 publications

    422 citations

  3. University of California, Berkeley

    Berkeley, United States

    2 h-index

    5 publications

    1.2K citations

  4. Stanford University

    Stanford, United States

    1 h-index

    3 publications

    84 citations

  5. Ewha Womans University Medical Center

    Seoul, South Korea

    1 h-index

    8 publications

    544 citations

  6. University of Groningen

    Groningen, The Netherlands

    1 h-index

    1 publications

    65 citations

  7. Rensselaer Polytechnic Institute

    Troy, United States

    1 h-index

    1 publications

    203 citations

  8. Zhejiang University of Technology

    Hangzhou, China

    1 h-index

    5 publications

    155 citations

1–8 of 43

Venues

  1. Metabolic Engineering

    4 publications · 563 citations

    4

    h-index

  2. Journal of Agricultural and Food Chemistry

    3 publications · 88 citations

    3

    h-index

  3. ACS Synthetic Biology

    2 publications · 227 citations

    2

    h-index

  4. Systems Microbiology and Biomanufacturing

    1 publications · 21 citations

    1

    h-index

  5. Applied Microbiology and Biotechnology

    1 publications · 68 citations

    1

    h-index

1–5