Concepedia

Post-translational Activation

Post-Translational Activation is a molecular mechanism within oncogene activation whereby a proto-oncogenic protein gains enhanced or dysregulated activity through covalent modifications, conformational changes, or proteolytic processing subsequent to its synthesis, without alteration of the underlying gene sequence.

315

Publications

21K

Citations

1.7K

Authors

572

Institutions

Publications per year

2017–2026

51

Parents

Publications

315

Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway

Peter Novick, C Field, Randy Schekman · Cell · 1980 · 1.8K citations · Full text

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Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity.

David G. Perregaux, Christopher A. Gabel · Journal of Biological Chemistry · 1994 · 759 citations · Full text

, , +17

Translational Activation of Snail1 and Other Developmentally Regulated Transcription Factors by YB-1 Promotes an Epithelial-Mesenchymal Transition

Valentina Evdokimova, Cristina E. Tognon, Tony Ng et al. · Cancer Cell · 2009 · 445 citations · Full text

, , +15

eIF3 targets cell-proliferation messenger RNAs for translational activation or repression

Amy S.Y. Lee, Philip J. Kranzusch, J.H.D. Cate · Nature · 2015 · 441 citations · Full text

, , +14

ATM‐dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post‐translational activation of p53 protein involving poly(ADP‐ribose) polymerase

Homayoun Vaziri, Michael D. West, Richard Allsopp et al. · The EMBO Journal · 1997 · 380 citations · Full text

, , +17

1–5 of 315

Authors

1.7K

  1. MY
    Masakane Yamashita

    Hokkaido University, Japan

    5 publications · 371 citations

    5

    h-index

  2. TK
    Tomoya Kotani

    Hokkaido University, Japan

    4 publications · 141 citations

    4

    h-index

  3. MS
    Mark S. Peterson

    University of Southern Mississippi, United States

    3 publications · 224 citations

    3

    h-index

  4. RC
    Ronald C. Wek

    Indiana University – Purdue University Indianapolis, United States

    3 publications · 234 citations

    3

    h-index

  5. PB
    Peter B. Bitterman

    University of Minnesota, United States

    3 publications · 224 citations

    3

    h-index

1–5 of 1.7K

Institutions

572

  1. Centre National de la Recherche Scientifique

    Paris, France

    11 h-index

    50 publications

    2.6K citations

  2. Inserm

    Paris, France

    10 h-index

    68 publications

    2.9K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    8 h-index

    27 publications

    2.5K citations

  4. Hokkaido University

    Sapporo, Japan

    6 h-index

    19 publications

    1K citations

  5. Cornell University

    Ithaca, United States

    6 h-index

    20 publications

    1.3K citations

  6. Harvard University

    Cambridge, United States

    6 h-index

    24 publications

    2.4K citations

  7. University of Vienna

    Vienna, Austria

    6 h-index

    29 publications

    2.7K citations

  8. Shanghai Jiao Tong University

    Shanghai, China

    5 h-index

    24 publications

    935 citations

1–8 of 572

Venues

  1. Journal of Biological Chemistry

    JBC · 42 publications · 3.7K citations

    32

    h-index

  2. PLoS ONE

    13 publications · 642 citations

    13

    h-index

  3. PubMed

    Repository · 12 publications · 547 citations

    11

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 7 publications · 1.3K citations

    7

    h-index

  5. Nucleic Acids Research

    7 publications · 474 citations

    7

    h-index

1–5