Concepedia

Post-pks Modification

Post-PKS Modification is a biochemical transformation process that specifically alters the core structure of polyketide synthase-derived natural products through enzymatic reactions such as oxidation, glycosylation, or methylation, thereby diversifying their chemical functionality and biological activity.

34

Publications

1.5K

Citations

186

Authors

60

Institutions

Publications per year

2017–2026

8

Parents

Publications

34

Genes for the Biosynthesis of the Fungal Polyketides Hypothemycin from <i>Hypomyces subiculosus</i> and Radicicol from <i>Pochonia chlamydosporia</i>

Christopher D. Reeves, Zhihao Hu, Ralph Reid et al. · Applied and Environmental Microbiology · 2008 · 148 citations

, , +15

Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequinone gene clusters

Koji Ichinose, Makoto Ozawa, Keiko Itou et al. · Microbiology · 2003 · 120 citations

, , +15

A Post-PKS Oxidation of the Amphotericin B Skeleton Predicted to be Critical for Channel Formation Is Not Required for Potent Antifungal Activity

Daniel S. Palacios, Thomas M. Anderson, Martin D. Burke · Journal of the American Chemical Society · 2007 · 99 citations · Full text

, , +15

Development of Transcription Factor-Based Designer Macrolide Biosensors for Metabolic Engineering and Synthetic Biology

Christian Kasey, Mounir Zerrad, Yiwei Li et al. · ACS Synthetic Biology · 2017 · 98 citations · Full text

, , +17

Natalamycin A, an ansamycin from a termite-associated Streptomyces sp.

Ki Hyun Kim, Timothy R. Ramadhar, Christine Beemelmanns et al. · Chemical Science · 2014 · 96 citations · Full text

, , +12

1–5 of 34

Authors

186

  1. KI
    Koji Ichinose

    The University of Tokyo, Japan

    3 publications · 176 citations

    3

    h-index

  2. YE
    Yutaka Ebizuka

    The University of Tokyo, Japan

    3 publications · 176 citations

    3

    h-index

  3. LB
    Linquan Bai

    Shanghai Jiao Tong University, China

    3 publications · 134 citations

    3

    h-index

  4. XN
    Xinjuan Ning

    Shanghai Jiao Tong University, China

    2 publications · 55 citations

    2

    h-index

  5. BP
    Bo Pang

    Chinese Academy of Sciences, China

    2 publications · 58 citations

    2

    h-index

1–5 of 186

Institutions

60

  1. Chinese Academy of Sciences

    Beijing, China

    5 h-index

    25 publications

    913 citations

  2. Shanghai Institute of Organic Chemistry

    Shanghai, China

    3 h-index

    16 publications

    536 citations

  3. Shandong University

    Jinan, China

    2 h-index

    12 publications

    316 citations

  4. University of Chinese Academy of Sciences

    Beijing, China

    2 h-index

    2 publications

    86 citations

  5. University of Washington

    Seattle, United States

    2 h-index

    9 publications

    552 citations

  6. Shanghai Jiao Tong University

    Shanghai, China

    2 h-index

    10 publications

    275 citations

  7. University of California, Los Angeles

    Los Angeles, United States

    2 h-index

    9 publications

    557 citations

  8. Dalian University of Technology

    Dalian, China

    2 h-index

    11 publications

    263 citations

1–8 of 60

Venues

  1. Journal of the American Chemical Society

    JACS · 4 publications · 313 citations

    4

    h-index

  2. Journal of Natural Products

    4 publications · 80 citations

    4

    h-index

  3. Organic Letters

    OL · 3 publications · 130 citations

    3

    h-index

  4. Chemical Science

    2 publications · 134 citations

    2

    h-index

  5. Biotechnology Journal

    2 publications · 55 citations

    2

    h-index

1–5