Concepedia

Positive Ionizable Features

Positive Ionizable Features is a pharmacophoric feature defined as an ionizable functional group capable of acquiring a positive charge under physiological conditions, typically through protonation of basic moieties such as amines, thereby enabling electrostatic interactions with negatively charged biological targets.

18

Publications

1.2K

Citations

95

Authors

31

Institutions

Publications per year

2017–2026

2

Parents

Publications

18

Three-Dimensional Quantitative Structure-Activity Relationship for Inhibition of Human Ether-a-Go-Go-Related Gene Potassium Channel

Sean Ekins, William Crumb, R. Dustan Sarazan et al. · Journal of Pharmacology and Experimental Therapeutics · 2002 · 261 citations

, , +17

Influence of Molecular Structure on Substrate Binding to the Human Organic Cation Transporter, hOCT1

Dallas Bednarczyk, Sean Ekins, James H. Wikel et al. · Molecular Pharmacology · 2003 · 113 citations · Full text

, , +17

An unexpected challenge: ionizable compounds in the REACH chemical space

Antonio Franco, Andrea Ferranti, Claus Davidsen et al. · The International Journal of Life Cycle Assessment · 2010 · 110 citations

, , +14

A Three-Dimensional Pharmacophore Model for 5-Hydroxytryptamine<sub>6</sub>(5-HT<sub>6</sub>) Receptor Antagonists

María L. López-Rodrı́guez, Bellinda Benhamú, T. de la Fuente et al. · Journal of Medicinal Chemistry · 2005 · 89 citations · Full text

, , +17

Nonacidic Farnesoid X Receptor Modulators

Daniel Flesch, Sun-Yee Cheung, Jurema Schmidt et al. · Journal of Medicinal Chemistry · 2017 · 85 citations · Full text

, , +16

1–5 of 18

Authors

95

  1. SE
    Sean Ekins

    Collaborations Pharmaceuticals (United States), United States

    4 publications · 423 citations

    4

    h-index

  2. EL
    Erik Laurini

    University of Trieste, Italy

    2 publications · 130 citations

    2

    h-index

  3. JH
    James H. Wikel

    Eli Lilly (United States), United States

    2 publications · 374 citations

    2

    h-index

  4. JE
    James E. Polli

    University of Maryland, Baltimore, United States

    2 publications · 49 citations

    2

    h-index

  5. BB
    Bellinda Benhamú

    Universidad Complutense de Madrid, Spain

    2 publications · 159 citations

    2

    h-index

1–5 of 95

Institutions

31

  1. Eli Lilly (United States)

    Indianapolis, United States

    2 h-index

    5 publications

    713 citations

  2. University of Trieste

    Trieste, Italy

    2 h-index

    13 publications

    929 citations

  3. University of Maryland, Baltimore

    Baltimore, United States

    2 h-index

    6 publications

    147 citations

  4. Universitat Autònoma de Barcelona

    Cerdanyola del Vallès, Spain

    2 h-index

    16 publications

    1.2K citations

  5. Medical University of Vienna

    Vienna, Austria

    1 h-index

    1 publications

    62 citations

  6. University of Tennessee at Knoxville

    Knoxville, United States

    1 h-index

    1 publications

    23 citations

  7. Technical University of Denmark

    Kongens Lyngby, Denmark

    1 h-index

    4 publications

    440 citations

  8. Universidad Nacional de Educación a Distancia

    Madrid, Spain

    1 h-index

    10 publications

    700 citations

1–8 of 31

Venues

  1. Journal of Medicinal Chemistry

    6 publications · 392 citations

    6

    h-index

  2. Molecular Pharmaceutics

    2 publications · 49 citations

    2

    h-index

  3. 1

    h-index

  4. Theoretical Chemistry Accounts

    1 publications · 10 citations

    1

    h-index

  5. The International Journal of Life Cycle Assessment

    LCA · 1 publications · 110 citations

    1

    h-index

1–5