Concepedia

Polyketide Synthase Complexes

Polyketide Synthase Complexes is a multienzyme complex that synthesizes polyketides through the sequential condensation of acyl-CoA precursors, distinguished by its modular organization and use of carrier proteins to shuttle intermediates between catalytic domains.

329

Publications

25.5K

Citations

1.3K

Authors

352

Institutions

Publications per year

2017–2026

62

Variants

Pks Complexes

Parents

Publications

329

Modular Organization of Genes Required for Complex Polyketide Biosynthesis

Stefano Donadio, Michael J. Staver, James B. McAlpine et al. · Science · 1991 · 909 citations

, , +17

Biosynthesis of Complex Polyketides in a Metabolically Engineered Strain of <i>E. coli</i>

Blaine A. Pfeifer, Suzanne J. Admiraal, Hugo Gramajo et al. · Science · 2001 · 760 citations

, , +17

Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis.

Joseph P. Noel, Joseph M. Jez, M.E. Bowman et al. · Nature Structural Biology · 1999 · 673 citations

, , +16

Modulation of Polyketide Synthase Activity by Accessory Proteins During Lovastatin Biosynthesis

Jonathan Kennedy, Karine Auclair, Steven G. Kendrew et al. · Science · 1999 · 660 citations

, , +16

An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea

Jesús Cortés, Stephen Haydock, Gareth A. Roberts et al. · Nature · 1990 · 631 citations

, , +13

1–5 of 329

Authors

1.3K

  1. CK
    Chaitan Khosla

    Stanford University, United States

    28 publications · 2.9K citations

    24

    h-index

  2. PF
    Peter F. Leadlay

    University of Cambridge, United Kingdom

    26 publications · 2.8K citations

    20

    h-index

  3. DE
    David E. Cane

    Brown University, United States

    19 publications · 1.9K citations

    19

    h-index

  4. JS
    James Staunton

    University of Cambridge, United Kingdom

    16 publications · 1.6K citations

    14

    h-index

  5. DH
    David H. Sherman

    University of Michigan, United States

    14 publications · 1.4K citations

    14

    h-index

1–5 of 1.3K

Institutions

352

  1. University of Cambridge

    Cambridge, United Kingdom

    25 h-index

    161 publications

    21.2K citations

  2. Stanford University

    Stanford, United States

    24 h-index

    104 publications

    8.9K citations

  3. Brown University

    Providence, United States

    19 h-index

    61 publications

    4.9K citations

  4. Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)

    Jena, Germany

    14 h-index

    51 publications

    3.7K citations

  5. University of Bristol

    Bristol, United Kingdom

    13 h-index

    66 publications

    4.5K citations

  6. University of California San Diego

    San Diego, United States

    13 h-index

    54 publications

    4.5K citations

  7. University of Michigan

    Ann Arbor, United States

    12 h-index

    59 publications

    7.6K citations

  8. The University of Texas at Austin

    Austin, United States

    12 h-index

    58 publications

    2.6K citations

1–8 of 352

Venues

  1. Chemistry & Biology

    43 publications · 4K citations

    37

    h-index

  2. Journal of the American Chemical Society

    JACS · 23 publications · 1.5K citations

    23

    h-index

  3. Biochemistry

    18 publications · 1.1K citations

    18

    h-index

  4. Gene

    17 publications · 1.9K citations

    17

    h-index

  5. Angewandte Chemie International Edition

    13 publications · 647 citations

    13

    h-index

1–5