Concepedia

Polyketide Synthase Cofactor Dependence

Polyketide Synthase Cofactor Dependence is a biochemical mechanism that specifies the requirement of specific non-proteinaceous cofactors for the catalytic activity and structural integrity of polyketide synthase enzymes during the biosynthesis of polyketide natural products.

30

Publications

1.7K

Citations

132

Authors

40

Institutions

Publications per year

2017–2026

3

Parents

Publications

30

Complete Reconstitution of a Highly Reducing Iterative Polyketide Synthase

Magali Suzanne, Jesse W.-H. Li, Jin Wook Choi et al. · Science · 2009 · 385 citations · Full text

, , +17

Structural rearrangements of a polyketide synthase module during its catalytic cycle

Jonathan R. Whicher, Somnath Dutta, Douglas A. Hansen et al. · Nature · 2014 · 197 citations

, , +16

Engineering cofactor and transport mechanisms in Saccharomyces cerevisiae for enhanced acetyl-CoA and polyketide biosynthesis

Javier Cárdenas, Nancy A. Da Silva · Metabolic Engineering · 2016 · 101 citations

, , +16

Structural and Functional Analysis of A-Type Ketoreductases from the Amphotericin Modular Polyketide Synthase

Jianting Zheng, C. Taylor, Shawn K. Piasecki et al. · Structure · 2010 · 92 citations · Full text

, , +16

Structural Analysis of Actinorhodin Polyketide Ketoreductase:  Cofactor Binding and Substrate Specificity

Tyler P. Korman, J.A. Hill, Thanh Vu et al. · Biochemistry · 2004 · 73 citations · Full text

, , +16

1–5 of 30

Authors

132

  1. LK
    Leonard Katz

    Abbott Fund, United States

    3 publications · 80 citations

    3

    h-index

  2. PF
    Peter F. Leadlay

    University of Cambridge, United Kingdom

    3 publications · 73 citations

    3

    h-index

  3. JS
    James Staunton

    University of Cambridge, United Kingdom

    3 publications · 73 citations

    3

    h-index

  4. CK
    Chaitan Khosla

    Stanford University, United States

    2 publications · 50 citations

    2

    h-index

  5. SH
    Sandeep Handa

    University of Leicester, United Kingdom

    2 publications · 54 citations

    2

    h-index

1–5 of 132

Institutions

40

  1. University of California, Irvine

    Irvine, United States

    4 h-index

    11 publications

    1.8K citations

  2. University of Cambridge

    Cambridge, United Kingdom

    4 h-index

    16 publications

    496 citations

  3. University of California, Berkeley

    Berkeley, United States

    3 h-index

    12 publications

    183 citations

  4. University of Washington

    Seattle, United States

    2 h-index

    4 publications

    108 citations

  5. The University of Texas at Austin

    Austin, United States

    2 h-index

    6 publications

    482 citations

  6. Stanford University

    Stanford, United States

    2 h-index

    4 publications

    100 citations

  7. University of California, Los Angeles

    Los Angeles, United States

    2 h-index

    5 publications

    1.6K citations

  8. National University of Rosario

    Rosario, Argentina

    1 h-index

    1 publications

    21 citations

1–8 of 40

Venues

  1. Methods in enzymology on CD-ROM/Methods in enzymology

    Book series · 4 publications · 183 citations

    4

    h-index

  2. Chemistry & Biology

    4 publications · 210 citations

    4

    h-index

  3. Archives of Microbiology

    2 publications · 36 citations

    2

    h-index

  4. Metabolic Engineering

    2 publications · 133 citations

    2

    h-index

  5. Nature Chemical Biology

    2 publications · 99 citations

    2

    h-index

1–5