Concepedia

Poly(a)-tail-dependent Translation

Poly(A)-Tail-Dependent Translation is a mechanism of translational regulation in which the efficiency of mRNA translation is enhanced by the interaction between the polyadenylate (poly(A)) tail and the 5' cap structure, mediated by poly(A)-binding protein (PABP) and eukaryotic initiation factors, thereby promoting ribosome recruitment and circularization of the mRNA.

459

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38.4K

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1.6K

Authors

471

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Publications per year

2017–2026

57

Parents

Publications

459

The cap and poly(A) tail function synergistically to regulate mRNA translational efficiency.

Daniel Gallie · Genes & Development · 1991 · 858 citations · Full text

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Poly(A)-tail profiling reveals an embryonic switch in translational control

Alexander O. Subtelny, Stephen W. Eichhorn, Grace R. Chen et al. · Nature · 2014 · 694 citations · Full text

, , +14

Association of the yeast poly(A) tail binding protein with translation initiation factor eIF‐4G.

Salvador Z. Tarun, Alan B. Sachs · The EMBO Journal · 1996 · 687 citations · Full text

, , +14

A newly identified N‐terminal amino acid sequence of human eIF4G binds poly(A)‐binding protein and functions in poly(A)‐dependent translation

Hiroaki Imataka · The EMBO Journal · 1998 · 567 citations

, , +14

The poly(A) binding protein is required for poly(A) shortening and 60S ribosomal subunit-dependent translation initiation

Alan B. Sachs, Ronald W. Davis · Cell · 1989 · 563 citations

, , +14

1–5 of 459

Authors

1.6K

  1. NS
    Nahum Sonenberg

    McGill University, Canada

    23 publications · 2.5K citations

    22

    h-index

  2. DG
    Daniel Gallie

    University of California, Riverside, United States

    22 publications · 2.6K citations

    18

    h-index

  3. YV
    Yuri V. Svitkin

    McGill University, Canada

    11 publications · 1.4K citations

    11

    h-index

  4. AB
    Alan B. Sachs

    University of California, Berkeley, United States

    9 publications · 2.5K citations

    9

    h-index

  5. HI
    Hiroaki Imataka

    McGill University, Canada

    9 publications · 1.5K citations

    9

    h-index

1–5 of 1.6K

Institutions

471

  1. McGill University

    Montreal, Canada

    22 h-index

    83 publications

    10.7K citations

  2. University of California, Riverside

    Riverside, United States

    17 h-index

    43 publications

    4K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    17 h-index

    42 publications

    7.7K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    12 h-index

    43 publications

    3K citations

  5. University of Massachusetts Chan Medical School

    Worcester, United States

    12 h-index

    28 publications

    3.7K citations

  6. University of Wisconsin–Madison

    Madison, United States

    12 h-index

    35 publications

    4.7K citations

  7. University of California, Berkeley

    Berkeley, United States

    11 h-index

    22 publications

    5.3K citations

  8. Massachusetts Institute of Technology

    Cambridge, United States

    11 h-index

    45 publications

    10.1K citations

1–8 of 471

Venues

  1. Molecular and Cellular Biology

    MCB · 40 publications · 4.5K citations

    34

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  2. Journal of Biological Chemistry

    JBC · 37 publications · 3.4K citations

    32

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  3. Nucleic Acids Research

    38 publications · 2.3K citations

    27

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  4. RNA

    26 publications · 1.7K citations

    23

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  5. Proceedings of the National Academy of Sciences

    PNAS · 16 publications · 1.4K citations

    16

    h-index

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