Concepedia

Plasmid Burden

Plasmid Burden is a metabolic cost distinct from chromosomal gene expression, arising from the maintenance and replication of extrachromosomal DNA elements in host cells, particularly in microbial systems engineering.

29

Publications

2.2K

Citations

126

Authors

56

Institutions

Publications per year

2017–2026

8

Variants

Plasmid Metabolic Burden

Parents

Publications

29

Plasmid‐encoded protein: The principal factor in the “metabolic burden” associated with recombinant bacteria

William E. Bentley, N. Mirjalili, Dana C. Andersen et al. · Biotechnology and Bioengineering · 1990 · 538 citations

, , +16

Characterization of plasmid burden and copy number in<i>Saccharomyces cerevisiae</i>for optimization of metabolic engineering applications

Ashty S. Karim, Kathleen A. Curran, Hal S. Alper · FEMS Yeast Research · 2012 · 227 citations · Full text

, , +17

A plasmid system with tunable copy number

Miles V. Rouches, Yasu Xu, Louis B. G. Cortes et al. · Nature Communications · 2022 · 132 citations · Full text

, , +17

Characterization of the metabolic burden on <i>Escherichia coli</i> DH1 cells imposed by the presence of a plasmid containing a gene therapy sequence

Aleksei Rozkov, Claudio Avignone–Rossa, P.F. Ertl et al. · Biotechnology and Bioengineering · 2004 · 117 citations

, , +17

Global transcriptional analysis of metabolic burden due to plasmid maintenance in Escherichia coli DH5α during batch fermentation

Dave Siak‐Wei Ow, Peter Morin Nissom, Robin Philp et al. · Enzyme and Microbial Technology · 2006 · 109 citations

, , +16

1–5 of 29

Authors

126

  1. RH
    Robert H. Davis

    University of Colorado Boulder, United States

    3 publications · 660 citations

    3

    h-index

  2. DS
    Dhinakar S. Kompala

    University of Colorado Boulder, United States

    2 publications · 635 citations

    2

    h-index

  3. WE
    William E. Bentley

    University of Maryland, College Park, United States

    2 publications · 635 citations

    2

    h-index

  4. DC
    Dana C. Andersen

    University of Alberta, Canada

    2 publications · 635 citations

    2

    h-index

  5. NM
    N. Mirjalili

    University College London, United Kingdom

    2 publications · 635 citations

    2

    h-index

1–5 of 126

Institutions

56

  1. University of Colorado Boulder

    Boulder, United States

    3 h-index

    12 publications

    3.2K citations

  2. Cornell University

    Ithaca, United States

    2 h-index

    7 publications

    660 citations

  3. London School of Hygiene & Tropical Medicine

    London, United Kingdom

    2 h-index

    4 publications

    267 citations

  4. National University of Singapore

    Singapore, Singapore

    2 h-index

    5 publications

    335 citations

  5. Bioprocessing Technology Institute

    Singapore, Singapore

    2 h-index

    9 publications

    701 citations

  6. The University of Texas at Austin

    Austin, United States

    2 h-index

    12 publications

    987 citations

  7. Universidad Nacional Autónoma de México

    Mexico City, Mexico

    2 h-index

    5 publications

    365 citations

  8. Centro de Astrobiología

    Torrejón de Ardoz, Spain

    1 h-index

    1 publications

    27 citations

1–8 of 56

Venues

  1. Biotechnology and Bioengineering

    8 publications · 951 citations

    8

    h-index

  2. Biotechnology Progress

    4 publications · 169 citations

    4

    h-index

  3. Applied and Environmental Microbiology

    AEM · 2 publications · 74 citations

    2

    h-index

  4. Nature Communications

    2 publications · 166 citations

    2

    h-index

  5. Genome Medicine

    2 publications · 131 citations

    2

    h-index

1–5