Concepedia

Phosphorylation Cascade Dynamics

Phosphorylation Cascade Dynamics is a biochemical signaling mechanism characterized by the sequential activation of protein kinases through phosphorylation events, wherein each kinase in the cascade amplifies the signal by catalyzing the phosphorylation of multiple downstream targets, thereby enhancing the sensitivity and specificity of cellular responses to extracellular stimuli.

21

Publications

2.3K

Citations

91

Authors

51

Institutions

Publications per year

2017–2026

3

Parents

Publications

21

Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors

Birgit Schoeberl, Claudia Eichler-Jonsson, Ernst Dieter Gilles et al. · Nature Biotechnology · 2002 · 969 citations

, , +16

Xenopus MAP kinase activator: identification and function as a key intermediate in the phosphorylation cascade.

Shuichi Matsuda, Hidetaka Kosako, Kei Takenaka et al. · The EMBO Journal · 1992 · 268 citations · Full text

, , +13

Unlimited multistability in multisite phosphorylation systems

Matthew Thomson, Jeremy Gunawardena · Nature · 2009 · 258 citations · Full text

, , +8

The JNK Cascade as a Biochemical Switch in Mammalian Cells

Christoph P. Bagowski, Jaya Besser, Christian Frey et al. · Current Biology · 2003 · 139 citations · Full text

, , +14

A Phosphorylation Cycle Shapes Gradients of the DYRK Family Kinase Pom1 at the Plasma Membrane

Olivier Hachet, Martine Berthelot‐Grosjean, Kyriakos Kokkoris et al. · Cell · 2011 · 117 citations · Full text

, , +14

1–5 of 21

Authors

91

  1. HK
    Hidetaka Kosako

    Tokushima University, Japan

    2 publications · 335 citations

    2

    h-index

  2. JK
    Jung‐Min Kee

    Ulsan National Institute of Science and Technology, South Korea

    1 publications · 11 citations

    1

    h-index

  3. KK
    Kyriakos Kokkoris

    University of Lausanne, Switzerland

    1 publications · 117 citations

    1

    h-index

  4. LB
    Lee Bardwell

    University of California, Irvine, United States

    1 publications · 42 citations

    1

    h-index

  5. GF
    G.M.N. Ferreira

    University of the Witwatersrand, South Africa

    1 publications · 25 citations

    1

    h-index

1–5 of 91

Institutions

51

  1. Tokyo University of Science

    Tokyo, Japan

    2 h-index

    10 publications

    2.2K citations

  2. Quantitative BioSciences

    Solana Beach, United States

    2 h-index

    2 publications

    97 citations

  3. Berlin Institute of Health at Charité - Universitätsmedizin Berlin

    Berlin, Germany

    1 h-index

    2 publications

    38 citations

  4. Charité - Universitätsmedizin Berlin

    Berlin, Germany

    1 h-index

    3 publications

    57 citations

  5. University of California, Irvine

    Irvine, United States

    1 h-index

    2 publications

    84 citations

  6. Imperial College London

    London, United Kingdom

    1 h-index

    3 publications

    90 citations

  7. Thomas Jefferson University

    Philadelphia, United States

    1 h-index

    1 publications

    83 citations

  8. University of South Carolina

    Columbia, United States

    1 h-index

    1 publications

    42 citations

1–8 of 51

Venues

  1. Biophysical Journal

    2 publications · 65 citations

    2

    h-index

  2. Developmental Biology

    1 publications · 31 citations

    1

    h-index

  3. Chemical Communications

    ChemComm · 1 publications · 11 citations

    1

    h-index

  4. Current Biology

    1 publications · 139 citations

    1

    h-index

  5. Biosystems

    1 publications · 25 citations

    1

    h-index

1–5